Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Capillary Electrophoresis: Applications

Capillary Electrophoresis: Applications

Capillary electrophoretic separations offer various modes, each with unique applications. These modes include capillary zone electrophoresis, capillary gel electrophoresis, capillary array electrophoresis, capillary isoelectric focusing, capillary isotachophoresis, micellar electrokinetic chromatography, and capillary electrochromatography.
Capillary zone electrophoresis (CZE) separates ionic components based on their electrophoretic mobility. It has been used to separate proteins, amino acids,...

Micelles

Micelles

Micelle formation is an intricate process that hinges on the properties of amphiphilic or amphipathic molecules and the conditions of the system in which they are found. Amphiphilic molecules, which have both hydrophilic (water-attracting) and hydrophobic (water-repelling) parts, play a critical role in this process.In aqueous environments, these molecules arrange themselves such that their hydrophilic heads are turned towards the water phase, while their hydrophobic tails are oriented away...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Correlates of mobile device use in young children: a systematic review and meta-analysis.

BMJ public health·2026

Same author

Pressure injury severity and trajectory: A 5-year cohort study in an Australian health district.

Journal of tissue viability·2026

Same author

Clinicians' Perspectives of the Pressure Injury Treatment Advisory 'PITA' Quick Guide: An Evaluation Across Three Australian Healthcare Settings.

International wound journal·2026

Same author

A Liquid Thickener Presentation Format for the Therapeutic Management of Dysphagia-A Promising Step Forward in Addressing the Challenges Associated With Thickened Fluids in Swallowing Disorders?

International journal of language & communication disorders·2025

Same author

Diphenyl carbonate crosslinked β-cyclodextrin nanosponge-based topically applied gel for co-delivery of baricitinib and tenoxicam in rheumatoid arthritis.

European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences·2025

Same author

Pre-Registration Mental Health Nursing Students Who Witness Self-Harm Amongst Service Users During Placement: A Cross-Sectional Study.

International journal of mental health nursing·2025

Search research articles

Related Experiment Video

Updated: May 8, 2026

A Method for Determination and Simulation of Permeability and Diffusion in a 3D Tissue Model in a Membrane Insert System for Multi-well Plates

A Method for Determination and Simulation of Permeability and Diffusion in a 3D Tissue Model in a Membrane Insert System for Multi-well Plates

Published on: February 23, 2018

Modelling skin permeability with micellar liquid chromatography.

Laura J Waters¹, Yasser Shahzad, John Stephenson

¹School of Applied Sciences, University of Huddersfield, Queensgate, Huddersfield HD1 3DH, UK.

European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences

|August 17, 2013

Summary

This summary is machine-generated.

Micellar liquid chromatography (MLC) can predict skin permeation for drugs. This method offers a robust alternative to traditional partition coefficient measurements, enhancing predictions of drug skin permeability (K(p)).

Keywords:

Chromatography Micellar Modelling Partition coefficient Permeability

More Related Videos

Development, Characterization, and Evaluation of CAGE-based Ionic Liquid Systems for Transdermal Delivery

Development, Characterization, and Evaluation of CAGE-based Ionic Liquid Systems for Transdermal Delivery

Published on: September 26, 2025

Assembly of Cell Mimicking Supported and Suspended Lipid Bilayer Models for the Study of Molecular Interactions

Assembly of Cell Mimicking Supported and Suspended Lipid Bilayer Models for the Study of Molecular Interactions

Published on: August 3, 2021

Related Experiment Videos

Last Updated: May 8, 2026

A Method for Determination and Simulation of Permeability and Diffusion in a 3D Tissue Model in a Membrane Insert System for Multi-well Plates

A Method for Determination and Simulation of Permeability and Diffusion in a 3D Tissue Model in a Membrane Insert System for Multi-well Plates

Published on: February 23, 2018

Development, Characterization, and Evaluation of CAGE-based Ionic Liquid Systems for Transdermal Delivery

Development, Characterization, and Evaluation of CAGE-based Ionic Liquid Systems for Transdermal Delivery

Published on: September 26, 2025

Assembly of Cell Mimicking Supported and Suspended Lipid Bilayer Models for the Study of Molecular Interactions

Assembly of Cell Mimicking Supported and Suspended Lipid Bilayer Models for the Study of Molecular Interactions

Published on: August 3, 2021

Area of Science:

Pharmacokinetics and Drug Delivery
Chromatographic Science
Dermatological Research

Background:

Micellar liquid chromatography (MLC) is a chromatographic technique.
The octanol-water partition coefficient (logP(ow)) is a traditional parameter for predicting drug behavior.
MLC has been used to predict partition coefficient values (logP) but not skin permeability (K(p)).

Purpose of the Study:

To evaluate the application of MLC for predicting skin permeation.
To establish a quantitative relationship between MLC-derived values and skin permeability.
To compare MLC with traditional methods for predicting drug skin penetration.

Main Methods:

A series of model compounds were analyzed using micellar liquid chromatography (MLC).
Chromatographically determined partition coefficients (logP(mw)) were obtained.
Quantitative relationships between logP(mw) and skin permeability (K(p)) were established.

Main Results:

MLC successfully predicted skin permeation for model compounds.
Replacing logP(ow) with logP(mw) resulted in a robust quantitative partition-permeability relationship.
MLC demonstrated enhanced predictive ability for drug skin permeability (K(p)).

Conclusions:

MLC is a valuable tool for predicting skin permeation.
MLC offers a robust and potentially advantageous alternative to traditional methods for assessing drug skin penetration.
This study establishes MLC as a viable technique for skin permeability modeling.