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A High Throughput, Multiplexed and Targeted Proteomic CSF Assay to Quantify Neurodegenerative Biomarkers and Apolipoprotein E Isoforms Status
Published on: October 20, 2016
Cognitive impairment in neurological diseases: lessons from apolipoprotein E
Jiong Shi1, Pengcheng Han, Sandra M Kuniyoshi
1Department of Neurology, Barrow Neurological Institute, Phoenix, AZ, USA.
Journal of Alzheimer'S Disease : JAD
|August 17, 2013
Summary
Apolipoprotein E4 (ApoE4) worsens cognitive decline in neurological diseases like Alzheimer's and traumatic brain injury. Understanding ApoE's role in these conditions reveals insights into cognitive impairment mechanisms.
Area of Science:
- Neuroscience
- Genetics
- Neurology
Background:
- Apolipoprotein E4 (ApoE4) is linked to earlier onset and faster progression of Alzheimer's disease.
- Emerging evidence implicates ApoE isoforms in various other neurological disorders.
Purpose of the Study:
- To explore the multifaceted role of ApoE isoforms in cognitive function across diverse neurological conditions.
- To investigate the intersection and divergence of ApoE's influence in diseases such as Alzheimer's, traumatic brain injury, cerebrovascular disease, delirium, and multiple sclerosis.
Main Methods:
- Review of recent studies and existing evidence on ApoE isoforms and cognitive deficits.
- Analysis of ApoE's impact on neuroinflammation and cognitive decline in different patient populations.
Main Results:
- ApoE4 is associated with increased cognitive deficits in patients with traumatic brain injury, cerebrovascular disease, and delirium.
- ApoE isoforms influence cognition in multiple sclerosis, highlighting its neurodegenerative aspects and the role of neuroinflammation.
Conclusions:
- Apolipoprotein E4 significantly impacts cognitive function across a spectrum of neurological diseases.
- Investigating ApoE's varied roles provides critical insights into the "two-hit" mechanism underlying cognitive decline.
Keywords:
Alzheimer's diseaseaneurysmapolipoprotein Edeliriummultiple sclerosisstroketraumatic brain injuryMore Related Videos
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