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Optical Coherence Tomography Based Biomechanical Fluid-Structure Interaction Analysis of Coronary Atherosclerosis Progression

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Correlation between Reynolds number and eccentricity effect in stenosed artery models.

Ashkan Javadzadegan¹, Yasutomo Shimizu, Masud Behnia

¹Mechanical and Mechatronic Engineering, School of Aerospace, The University of Sydney, Sydney, NSW, Australia.

Technology and Health Care : Official Journal of the European Society for Engineering and Medicine

|August 17, 2013

Summary

Lesion eccentricity in coronary arteries significantly impacts flow recirculation and shear strain. However, this effect becomes negligible as the Reynolds number (Re) increases.

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Area of Science:

Cardiovascular physiology
Biomedical engineering
Fluid dynamics

Background:

Flow recirculation and shear strain are physiological processes in coronary arteries linked to disease.
Lesion eccentricity, independent of stenosis severity, influences these flow dynamics.

Purpose of the Study:

To analyze how lesion eccentricity affects transient flow behavior in a coronary artery model.
To investigate the correlation between Reynolds number (Re) and the impact of eccentricity on flow patterns.

Main Methods:

Utilized transient particle image velocimetry (PIV) in silicone models.
Compared models with eccentric versus concentric 70% diameter stenosis.

Main Results:

The eccentric model exhibited larger recirculation zones, higher shear strain rates, and greater axial velocities.
Eccentricity's greatest impact was on recirculation zone length, and lowest on shear strain rate.
A negative correlation was found between Reynolds number (Re) and eccentricity's effects on velocity, shear strain, and recirculation length.

Conclusions:

The influence of lesion eccentricity on coronary artery flow dynamics diminishes as the Reynolds number (Re) rises.
Higher Re renders eccentricity's impact on flow behavior negligible.