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In Vivo Functional Study of Disease-associated Rare Human Variants Using Drosophila

In Vivo Functional Study of Disease-associated Rare Human Variants Using Drosophila

Published on: August 20, 2019

CRY2 genetic variants associate with dysthymia.

Leena Kovanen¹, Mari Kaunisto, Kati Donner

¹National Institute for Health and Welfare-THL, Department of Mental Health and Substance Abuse Services, Helsinki, Finland. leena.kovanen@thl.fi

|August 17, 2013

Summary

Genetic variations in the CRY2 gene are linked to dysthymia, a type of depressive disorder. This research highlights the role of circadian clock genes in mood disorders.

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An Allele-specific Gene Expression Assay to Test the Functional Basis of Genetic Associations

An Allele-specific Gene Expression Assay to Test the Functional Basis of Genetic Associations

Published on: November 3, 2010

Area of Science:

Molecular genetics
Neuroscience
Psychiatry

Background:

Mood disorders are frequently associated with circadian rhythm disruptions.
Molecular genetics studies have identified links between circadian clock genes and mood disorders.

Purpose of the Study:

To investigate the association of circadian clock genes CRY1 and CRY2, and TTC1 with depressive and anxiety disorders.
To examine specific single-nucleotide polymorphisms (SNPs) within these genes.

Main Methods:

Genotyping of 48 selected SNPs in 5910 individuals from a population-based sample.
Diagnosis of major depressive disorder, dysthymia, and anxiety disorders using the M-CIDI structured interview.
Analysis of SNP associations with depressive and anxiety symptoms using logistic and linear regression models.

Main Results:

Four genetic variants in the CRY2 gene (rs10838524, rs7121611, rs7945565, rs1401419) showed a significant association with dysthymia (q<0.05).

Conclusions:

The findings support a role for the CRY2 gene in the pathophysiology of mood disorders.
Previous associations of CRY2 with winter depression and bipolar disorder further strengthen its link to mood regulation.