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Updated: Aug 16, 2026

Microiontophoresis and Micromanipulation for Intravital Fluorescence Imaging of the Microcirculation
Published on: June 10, 2011
[Coincidence of hypertensive fundus changes and regulatory disorders of peripheral microcirculation. II--Skeletal
F Jung1, W Kolepke, H Kiesewetter
1Abteilung für Klinische Haemostaseologie und Transfusionsmedizin, Universität des Saarlandes, Homburg.
Abstract:
In patients with hypertensive fundus changes considerable morphologic changes of the entire vascular system may be assumed. In the present study, the effects of these processes on the partial oxygen pressure of the skeletal musculature were investigated in 62 patients via a macro puncture electrode placed in the tibial muscle. The extent of fundus changes and the reduction in muscular partial oxygen pressure were found to be correlated. With advancing stages of fundus changes, blood flow measured in the common carotid artery decreased. Vascular changes which are clearly recognizable in the hypertensive fundus thus appear to be accompanied by a deterioration in partial oxygen pressure in muscular tissue and restriction of flow in the macrocirculation.
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