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Updated: May 8, 2026

Evaluation of the In vivo Antitumor Activity of Polyanhydride IL-1α Nanoparticles
Published on: June 28, 2021
Successful treatment of Erdheim-Chester disease by interleukin-1 receptor antagonist protein
Audrey Courcoul1, Emmanuelle Vignot1, Roland Chapurlat1
1Inserm UMR1033, université de Lyon, Hospices Civils de Lyon, Department of rheumatology, Pavillon F, hospital Edouard-Herriot, 5, place d'Arsonval, 69003 Lyon, France.
Abstract:
Erdheim-Chester disease is a rare non-langerhans systemic histiocytosis of unknown origin, associated with bone diseases and severe visceral complications. Therapies have been disappointing. A recombinant form of interleukin-1 receptor antagonist (anakinra) has been used in a few cases when usual treatment fails. We report a new case of successfully interleukin-1 receptor antagonist treatment in Erdheim-Chester disease.

