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Intracranial Orthotopic Allografting of Medulloblastoma Cells in Immunocompromised Mice
Published on: October 3, 2010
Goldenhar syndrome and medulloblastoma: a coincidental association? The first case report
Dror Aizenbud1, Natasha V Shoham1, Shlomi Constantini2
1Orthodontic and Craniofacial Department, School of Graduate Dentistry, Rambam Health Care Campus, P.O. Box 9602, Haifa 31096, Israel.
Background:
Features of Goldenhar syndrome include several craniofacial anomalies of structures derived from the first and second pharyngeal arches, as well as vertebral, cardiac and renal systems abnormalities. In addition, Goldenhar patients were reported to manifest a variety of central nervous system anomalies and several types of neoplasias.
Case History And Discussion:
The first case of medulloblastoma in a patient with Goldenhar syndrome is presented here. There is no clear association between these two pathologies. We speculate that aberrant events during the migration of neural crest cells in early stages of development could be the basis of an association between medulloblastoma and Goldenhar syndrome. The case history suggests other possible etiological contributing factors to the development of medulloblastoma, such as patient's history of trauma and/or early childhood exposure to ionizing radiation.
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