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XIAP regulates caspase activity in degenerating axons

Nicolas Unsain1, Julia M Higgins, Kristen N Parker

  • 1Department of Neurology and Neurosurgery, Montreal Neurological Institute, McGill University, 3801 University Street, Montreal, Quebec H3A 2B4, Canada.

Cell Reports
|August 20, 2013
PubMed
Summary

The X-linked inhibitor of apoptosis protein (XIAP) prevents axonal degeneration by inhibiting caspases in dorsal root ganglion (DRG) neurons. Maintaining XIAP levels protects axons and supports proper nervous system development.

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