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Related Experiment Video

Updated: May 8, 2026

Robust Ligature-Induced Model of Murine Periodontitis for the Evaluation of Oral Neutrophils

Robust Ligature-Induced Model of Murine Periodontitis for the Evaluation of Oral Neutrophils

Published on: January 21, 2020

Tooth loss in aggressive periodontitis: a systematic review.

L Nibali¹, B C Farias, A Vajgel

¹Periodontology Unit and Department of Clinical Research, UCL Eastman Dental Institute, London, UK.

Journal of Dental Research

|August 20, 2013

Summary

Aggressive periodontitis (AgP) shows slow tooth loss, averaging 0.09 teeth per patient-year. Most treated AgP cases achieve long-term stability, indicating effective management strategies for this severe gum disease.

Keywords:

disease progression maintenance meta-analysis periodontal bone loss periodontal diseases periodontal pocket

Related Experiment Videos

Last Updated: May 8, 2026

Robust Ligature-Induced Model of Murine Periodontitis for the Evaluation of Oral Neutrophils

Robust Ligature-Induced Model of Murine Periodontitis for the Evaluation of Oral Neutrophils

Published on: January 21, 2020

Area of Science:

Dentistry
Periodontology
Oral Health Research

Background:

Aggressive periodontitis (AgP) is characterized by rapid disease progression compared to chronic periodontitis (CP).
Systematic investigations into disease progression and tooth loss in AgP are limited.
Previous terminology for AgP includes 'periodontosis', 'juvenile periodontitis', and 'early-onset periodontitis'.

Purpose of the Study:

To systematically review longitudinal studies on disease progression and tooth loss in aggressive periodontitis.
To quantify tooth loss as a key indicator of disease progression in AgP patients.
To assess the long-term stability of treated aggressive periodontitis cases.

Main Methods:

Systematic literature search of Ovid MEDLINE(®) and Embase databases.
Inclusion of longitudinal human studies with at least 5-year follow-up in AgP patients.
Meta-analysis performed for tooth loss due to heterogeneity in disease definition and data reporting.

Main Results:

16 studies were included from 1,601 initial titles.
Average tooth loss in AgP was 0.09 teeth per patient-year (95% C.I. = 0.06-0.16).
Tooth loss varied by diagnosis: 0.05 for localized AgP (LAgP), 0.14 for generalized AgP (GAgP), and 0.12 for unspecified AgP per patient-year.

Conclusions:

Most studies indicate good long-term stability in treated aggressive periodontitis cases.
The findings provide quantitative data on tooth loss, a critical measure of AgP progression.
Further research may be needed to address heterogeneity in AgP definitions and data collection.