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Related Concept Videos

Anticoagulant Drugs: Low-Molecular-Weight Heparins01:30

Anticoagulant Drugs: Low-Molecular-Weight Heparins

Hemostasis is a crucial process that prevents excessive blood loss from damaged blood vessels. It involves various mechanisms such as vasoconstriction, platelet adhesion and activation, and fibrin formation. The importance of each mechanism depends on the type of vessel injury. In contrast, thrombosis is the abnormal formation of a blood clot within the blood vessels, leading to potential complications if the clot obstructs blood flow. Thrombosis can be caused by increased coagulability of the...
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Venous thrombosis requires effective prevention and treatment strategies to improve patient outcomes and reduce potential complications.Prevention StrategiesHealthcare providers must prioritize preventing venous thromboembolism (VTE) for all adult patients upon admission. Interventions depend on bleeding and thrombosis risk, medical history, current medications, diagnoses, planned procedures, and patient preferences. Patients on bed rest should change positions every two hours and, if not...
In Vitro Fertilization01:24

In Vitro Fertilization

In vitro fertilization (IVF) is a form of assisted reproductive technology where an egg is fertilized with sperm in a controlled laboratory environment before transferring the resulting embryo into the uterus. This process is designed to help individuals and couples experiencing difficulties conceiving.
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Related Experiment Video

Updated: May 8, 2026

Monitoring Blood Glucose in Mouse Offspring After Intracytoplasmic Sperm Injection
06:11

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Published on: May 17, 2024

Heparin for assisted reproduction.

Muhammad A Akhtar1, Shyamaly Sur, Nick Raine-Fenning

  • 1Clinical Reproductive Medicine Unit, University Hospitals, Coventry & Warwickshire NHS Trust, Clifford Bridge Road, Coventry, UK.

The Cochrane Database of Systematic Reviews
|August 20, 2013
PubMed
Summary
This summary is machine-generated.

Peri-implantation low molecular weight heparin (LMWH) may improve live birth rates in assisted reproduction, but evidence is limited and results are sensitive to statistical methods. Further research is needed to confirm benefits and assess side effects.

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Area of Science:

  • Reproductive Medicine
  • Pharmacology

Background:

  • Peri-implantation heparin is used in assisted reproduction to enhance implantation and clinical outcomes.
  • Proposed mechanisms include improved decidualization and favorable endometrial cytokine profiles.

Purpose of the Study:

  • To evaluate the efficacy of peri-implantation heparin in improving clinical outcomes for subfertile women undergoing assisted reproduction.

Main Methods:

  • Systematic review of randomized controlled trials (RCTs) using comprehensive search strategies.
  • Included studies administered peri-implantation low molecular weight heparin (LMWH) during IVF/ICSI.
  • Live birth rate was the primary outcome measure.

Main Results:

  • Three RCTs involving 386 women suggested improved live birth and clinical pregnancy rates with LMWH.
  • These findings were based on very low-quality evidence, high heterogeneity, and were sensitive to statistical models.
  • Adverse events like bruising and bleeding were reported, with potential increase upon longer duration of therapy.

Conclusions:

  • Peri-implantation LMWH may potentially improve live birth rates in assisted reproduction, but evidence is limited and of low quality.
  • Results are sensitive to statistical analysis, and side effects are a concern.
  • Further high-quality, multicenter trials are necessary to validate these findings and explore local application of heparin.