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An Orthotopic Bladder Cancer Model for Gene Delivery Studies
Published on: December 1, 2013
Squamous cell carcinoma in exstrophy of the bladder
Pramod Kumar Sharma1, Praveen Kumar Pandey, Mukesh Kumar Vijay
1Department of Urology, Institute of Post Graduate Medical Education and Research, Kolkata, India.
Korean Journal of Urology
|August 20, 2013
Summary
Bladder exstrophy, a rare congenital condition, carries a risk of malignancy. This case highlights squamous cell carcinoma developing in an unrepaired exstrophy, emphasizing the need for vigilance.
Area of Science:
- Urology
- Oncology
- Congenital Anomalies
Background:
- Bladder exstrophy is a rare congenital anomaly affecting approximately 1 in 50,000 newborns.
- The exstrophied bladder mucosa has a known malignant potential, with adenocarcinoma being most common, followed by squamous cell carcinoma.
- Malignant tumors associated with bladder exstrophy typically arise in the fourth and fifth decades of life.
Purpose of the Study:
- To present a case of squamous cell carcinoma developing in an unrepaired exstrophy of the bladder.
- To discuss the management of this rare clinical presentation.
- To review the existing literature on malignancy in bladder exstrophy.
Main Methods:
- Case report presentation.
- Review of medical literature pertaining to bladder exstrophy and associated malignancies.
Main Results:
- A case of squamous cell carcinoma in an unrepaired exstrophy of the bladder is detailed.
- The incidence and types of malignancies associated with bladder exstrophy are discussed.
- Typical age distribution for these tumors is noted.
Conclusions:
- Squamous cell carcinoma can develop in the setting of unrepaired bladder exstrophy.
- Vigilance for malignant transformation is crucial in patients with bladder exstrophy.
- Further literature review supports the understanding of this rare complication.
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