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Extraction of Plant-based Capsules for Microencapsulation Applications
Published on: November 9, 2016
Bioactive polyprenylated acylphloroglucinol derivatives from Hypericum cohaerens
Xia Liu1, Xing-Wei Yang, Chao-Qun Chen
1State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences , Kunming 650201, People's Republic of China.
Abstract:
Nine new polyprenylated acylphloroglucinol derivatives, hypercohins B-J (1-9), and nine known analogues were isolated from the aerial parts of Hypericum cohaerens. The structures of 1-9 were elucidated based on spectroscopic analysis, and the absolute configuration of 1 was confirmed by X-ray crystallographic analysis. The inhibitory activities of these isolates on acetylcholinesterase and five human tumor cell lines were tested, and hypercohins B-D (1-3) exhibited moderate inhibitory activity (IC₅₀ 5.8-17.9 μM) against the tested tumor cell lines.
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