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Alternatives in the selection of allograft bone
1Department of Orthopaedic Surgery, School of Medicine, University of California, San Francisco 94143.
Orthopedics
|August 1, 1990
Summary
Orthopedic surgeons can improve bone grafting choices by understanding allograft bone types. Fresh-frozen sterile bone is often the best alternative to autograft bone for reconstructive and tumor surgeries.
Area of Science:
- Orthopedic Surgery
- Biomaterials Science
- Tissue Engineering
Background:
- Allograft bone is frequently used in orthopedic reconstructive and tumor surgery.
- Many orthopedic surgeons lack familiarity with available allograft bone types.
- Informed selection of bone allografts is crucial for successful outcomes.
Purpose of the Study:
- To review mechanical, osteoinduction, and safety data for different allograft bone types.
- To provide orthopedic surgeons with information for making informed decisions on bone alternatives.
- To compare fresh-frozen, secondarily sterilized, and freeze-dried bone allografts.
Main Methods:
- Literature review and data synthesis on allograft bone properties.
- Analysis of mechanical strength data for various allograft preparations.
- Evaluation of osteoinductive potential and safety profiles of bone allografts.
Main Results:
- Sterile fresh-frozen bone exhibits optimal properties for most applications.
- Secondary sterilization methods may impact mechanical and biological characteristics.
- Freeze-dried bone presents distinct advantages and limitations compared to fresh-frozen allografts.
Conclusions:
- Understanding the risks and benefits of each allograft type empowers orthopedic surgeons.
- Fresh-frozen sterile-collection bone is recommended as the preferred substitute for autogenous bone.
- Further research may elucidate optimal processing for specific orthopedic applications.