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Downregulation of ERp57 expression is associated with poor prognosis in early-stage cervical cancer
Hyunsoo Chung1, Hanbyoul Cho, Candice Perry
1Tissue Array Research Program, Laboratory of Pathology, Center for Cancer Research, National Cancer Institute, National Institutes of Health , Bethesda, MD , USA .
Objective:
We investigated the clinical significance of ERp57 in the progression of cervical cancer.
Methods:
mRNA and protein expression of ERp57 in cervical neoplasias were examined.
Results:
ERp57 mRNA expression was significantly decreased in cervical cancers. Immunohistochemistry revealed that ERp57 expression in 123 cervical cancers was down-regulated compared to cervical intraepithelial neoplasias or normal tissues (p < 0.001). Low ERp57 expression was significantly associated with worse overall survival (HR = 12.19, p = 0.018).
Conclusions:
Low ERp57 expression independently predicts a poor outcome for patients with cervical cancer, supporting the notion that ERp57 may be a promising novel cancer target.
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