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Microbiota Analysis Using Two-step PCR and Next-generation 16S rRNA Gene Sequencing
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Respiratory tract rather than cutaneous atopic allergy inversely associate with multiple sclerosis: a case-control
Mohammad Ali Sahraian1, Sirous Jafarian, Sara Sheikhbahaei
1Sina MS Research Center, Sina Hospital, Tehran University of Medical Sciences(TUMS), Tehran, Iran.
Clinical Neurology and Neurosurgery
|August 21, 2013
Summary
Having a history of respiratory tract allergy (RTA) may reduce the risk of developing multiple sclerosis (MS). This study found a significant inverse association, suggesting RTA as a potential protective factor against MS.
Area of Science:
- Immunology
- Neurology
- Epidemiology
Background:
- Allergic conditions are linked to a reduced risk of Th1-mediated inflammatory diseases like multiple sclerosis (MS).
- Understanding the predictive value of atopic allergy in MS development is crucial.
Purpose of the Study:
- To investigate the association between lifetime atopic allergy and the risk of developing multiple sclerosis (MS).
Main Methods:
- A case-control study was conducted involving 195 MS cases and 195 controls.
- Participants were interviewed about their history of atopic allergies (respiratory tract allergy, cutaneous allergy, food/drug allergy) prior to MS diagnosis.
Main Results:
- A history of atopic allergy was reported by 64.1% of controls and 53.8% of cases (P=0.04).
- A positive history of respiratory tract allergy (RTA) (OR 0.43) or food/drug allergy (FDA) (OR 0.24) was inversely associated with MS risk.
- No significant association was found between cutaneous allergy (CA) history and MS.
Conclusions:
- A significant inverse association exists between RTA and MS, potentially due to a Th1/Th2 imbalance.
- History of RTA may serve as a clinically relevant risk-reducing factor for MS.
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