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Neonatal and pediatric antimicrobial stewardship programs in Europe-defining the research agenda

Ana Brett1, Julia Bielicki, Jason G Newland

  • 1From the *Infectious Diseases Unit and Emergency Service, Hospital Pediátrico, Centro, Hospitalar e Universitário de Coimbra, Coimbra, Portugal; †Paediatric Infectious Diseases Research Group, St George's University London, London, United Kingdom; ‡Division of Pediatric Infectious Diseases, Children's Mercy Hospital and Clinics, University of Missouri-Kansas City, MO; and §Paediatric Infectious Diseases Division, University Children's Hospital, Basel, Switzerland.

The Pediatric Infectious Disease Journal
|August 21, 2013
PubMed

Insights

Antimicrobial Stewardship Programs (ASPs) in pediatric and neonatal care are safe and effective. More research is needed on implementing ASPs in European hospitals to combat antimicrobial resistance.

Area of Science:

  • Infectious Diseases
  • Public Health
  • Pediatric Medicine

Background:

  • Suboptimal antimicrobial use is linked to rising antimicrobial resistance (AMR).
  • Antimicrobial Stewardship Programs (ASPs) aim to optimize antimicrobial use, improve patient care, and enhance cost-effectiveness.
  • AMR remains a significant global public health challenge despite international efforts.

Purpose of the Study:

  • To summarize approaches used in neonatal and pediatric ASPs, focusing on the European healthcare setting.
  • To review the current evidence on the safety, practicality, cost-effectiveness, and impact on AMR rates of pediatric ASPs.
  • To identify gaps in published data regarding pediatric ASP implementation in Europe.

Main Methods:

  • Review of existing literature on neonatal and pediatric ASPs.
  • Focus on studies conducted within European healthcare systems.
  • Analysis of reported outcomes including safety, cost-effectiveness, and impact on antimicrobial resistance.

Main Results:

  • Neonatal and pediatric ASPs are generally safe, practical, and cost-effective.
  • Evidence suggests a potential reduction in antimicrobial resistance rates with ASP implementation.
  • Published data on pediatric ASPs primarily originates from the United States, with limited reports from European children's hospitals.

Conclusions:

  • Optimal implementation strategies for pediatric ASPs in Europe are not yet established.
  • Further research is required, including novel study designs for ASP introduction.
  • Future studies should focus on monitoring clinical outcomes, cost-effectiveness, and refining AMR impact measurement.

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