Fundus autofluorescence patterns in primary intraocular lymphoma.

Area of Science:

• Ophthalmology
• Oncology
• Medical Imaging

Background:

• Primary intraocular lymphoma (IOL) is a rare malignancy affecting the eye.
• Accurate diagnosis and monitoring of IOL are crucial for patient outcomes.
• Fundus autofluorescence (FAF) is a non-invasive imaging technique that visualizes retinal pigment epithelium and photoreceptor function.

Purpose of the Study:

• To evaluate the diagnostic patterns of fundus autofluorescence (FAF) in patients diagnosed with primary intraocular lymphoma (IOL).
• To correlate FAF findings with clinical disease status and other imaging modalities like fluorescein angiography (FA) and spectral-domain optical coherence tomography (SD-OCT).

Main Methods:

• Retrospective review of 18 eyes from 10 patients with primary intraocular lymphoma who underwent FAF imaging.
• Analysis of FAF patterns, including hyperautofluorescence and hypoautofluorescence.
• Correlation of FAF findings with clinical data, FA, and SD-OCT results.

Main Results:

• Abnormal FAF patterns (granular hyper/hypoautofluorescence) were observed in 61% of eyes.
• Granular FAF patterns were associated with active lymphoma in the majority of cases.
• An "inversion" pattern, where FAF hyperautofluorescence corresponded to FA hypofluorescence, was noted in 36% of eyes.

Conclusions:

• Granularity on FAF is a significant indicator of active primary intraocular lymphoma.
• While FAF can show characteristic patterns, unremarkable FAF does not exclude active disease.
• FAF provides complementary information when used alongside FA and SD-OCT for diagnosing and monitoring IOL.