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Related Experiment Videos

Hydrodynamically balanced systems as sustained release dosage forms for propranolol hydrochloride.

D Khattar1, A Ahuja, R K Khar

  • 1Department of Pharmaceutics, Hamdard College of Pharmacy, New Dehli, India.

Die Pharmazie
|May 1, 1990
PubMed
Summary

Hydrodynamically balanced sustained release capsules (HBS) for propranolol hydrochloride were developed and tested. In vitro and in vivo studies confirmed their sustained drug release and floating capabilities.

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Area of Science:

  • Pharmaceutical Technology
  • Drug Delivery Systems
  • Pharmacokinetics

Background:

  • Oral drug delivery remains a cornerstone of therapeutic strategies.
  • Achieving sustained drug release is crucial for improving patient compliance and therapeutic efficacy.
  • Hydrodynamically balanced systems offer a unique approach to prolonging gastrointestinal drug transit time.

Purpose of the Study:

  • To formulate and characterize sustained release hydrodynamically balanced capsules (HBS) of propranolol hydrochloride.
  • To elucidate the drug release mechanism from the HBS formulation.
  • To evaluate the in vivo performance, specifically the floating behavior, of the HBS capsules.

Main Methods:

  • Formulation of propranolol hydrochloride into HBS capsules.

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  • In vitro dissolution testing to assess drug release profiles.
  • Endoscopic examination in vivo to observe capsule behavior within the gastrointestinal tract.

    • Main Results:

    • Successfully prepared HBS capsules demonstrated sustained release of propranolol hydrochloride.
    • In vitro data provided insights into the drug release kinetics.
    • In vivo endoscopic evaluation confirmed the floating characteristic of the HBS capsules in the gastrointestinal tract.

    Conclusions:

    • HBS capsules are a viable formulation for achieving sustained release of propranolol hydrochloride.
    • The formulation exhibits predictable in vitro release and demonstrates in vivo gastrointestinal residence time through floating.
    • This technology holds potential for optimizing propranolol therapy and other oral drug delivery applications.