Related Experiment Video
Updated: May 8, 2026

Functionalized Spirocyclic Heterocycle Synthesis and Cytotoxicity Assay
Published on: February 9, 2021
Synthesis and anticancer activity of some fused pyrimidines and related heterocycles
1Chemistry Department, Faculty of Science, Princess Nora Bint, AbdulRahman University, Riyadh, Saudi Arabia.
Abstract:
On account of the reported anticancer of pyrimidine and condensed pyrimidine, a new pyrimido [3,2-b]-1,2,4,5-tetrazine 3a , b , 5c , d , 6, 9, pyrimido [3,2-b]-1,2,4-triazine 10, 11, pyrimido [3,2-b]-1,2,4-triazole 12 and pyrimidine derivatives 1,2a , b , 4c , d , 8, 13, 14, 15 and 16 were synthesized through different chemical reactions. Structures of all synthesized compounds were supported by spectral and elemental analyses. The obtained compounds were evaluated for their in vitro antitumor activity against human liver cancer cell line (HEPG2).
Related Concept Videos
Five-Membered Heterocyclic Aromatic Compounds: Overview
Basicity of Heterocyclic Aromatic Amines
Physical Properties of Amines
Combined Effects of Drugs: Synergism
Such synergistic combinations...
Biosynthesis of Nucleic Acids
Inhibitors of Bacterial DNA Synthesis

