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Anticardiolipin antibodies in proliferative diabetic retinopathy: An additional risk factor

Maha Shahin1, Amany M El-Diasty, Mohamed Mabed

  • 1Ophthalmology Department, Faculty of Medicine, Mansoura University, Egypt.

Saudi Journal of Ophthalmology : Official Journal of the Saudi Ophthalmological Society
|August 21, 2013
PubMed

Insights

Anticardiolipin antibodies were found in 17.7% of diabetic patients with high-risk proliferative diabetic retinopathy (PDR). This suggests anticardiolipin antibodies may be an additional risk factor for developing PDR.

Area of Science:

  • Ophthalmology
  • Immunology
  • Endocrinology

Background:

  • Diabetic retinopathy (DR) is a leading cause of vision loss.
  • Proliferative diabetic retinopathy (PDR) represents an advanced stage with neovascularization.
  • Identifying risk factors for PDR is crucial for early intervention.

Purpose of the Study:

  • To determine the prevalence of anticardiolipin antibodies (aCL) in patients with high-risk PDR.
  • To investigate the association between aCL and PDR with high-risk criteria (HRC).

Main Methods:

  • A comparative study involving diabetic patients with PDR/HRC and control subjects without retinopathy.
  • Detection of anticardiolipin antibodies (aCL) in patient serum.
  • Statistical analysis, including Pearson's correlation, to assess associations.

Main Results:

  • Anticardiolipin antibodies were detected in 6 out of 34 (17.7%) patients with PDR and HRC.
  • No significant association was found between aCL antibodies and sex, diabetes type, diabetes duration, or patient age.
  • A statistically significant association was observed between the presence of aCL antibodies and PDR with HRC.

Conclusions:

  • The presence of anticardiolipin antibodies may serve as an additional risk factor for the development of proliferative diabetic retinopathy.
  • Further research is warranted to elucidate the role of aCL in the pathogenesis of PDR.
Abstract

Keywords:
Anticardiolipin antibodiesAntiphospholipids antibodiesDiabetic complicationsDiabetic retinopathyMedical retina

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