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Related Concept Videos

Glaucoma: Overview01:25

Glaucoma: Overview

Glaucoma is an eye condition characterized by increased intraocular pressure that damages the retina and optic nerve, leading to irreversible blindness if left untreated. The human eye has various components, including the cornea, iris, pupil, lens, and optic nerve. Aqueous humor is secreted by the epithelium of the ciliary body in the posterior chamber and flows through the trabecular meshwork and canal of Schlemm, maintaining normal intraocular pressure. The trabecular meshwork and the canal...
Angle Closure Glaucoma: Treatment01:28

Angle Closure Glaucoma: Treatment

Angle-closure glaucoma, or closed-angle glaucoma, is an eye condition where the iris bulges out and blocks the iridocorneal angle, resulting in a buildup of aqueous humor and increased intraocular pressure. Immediate medical attention is necessary due to the sudden onset of symptoms. The treatment for angle-closure glaucoma includes short-term and long-term approaches. Short-term treatment involves using eye drops like pilocarpine to lower intraocular pressure by increasing aqueous humor...
Open Angle Glaucoma: Treatment01:27

Open Angle Glaucoma: Treatment

In open-angle glaucoma, the iridocorneal angle remains open, but the trabecular meshwork becomes stiff, slowing down the outflow of aqueous humor. This causes a buildup of aqueous humor in the anterior chamber, leading to a sudden increase in intraocular pressure. The treatment for open-angle glaucoma focuses on reducing the elevated intraocular pressure by either decreasing the secretion of aqueous humor or increasing its outflow.
Drugs such as carbonic anhydrase inhibitors, α2- and...
Ophthalmic Drug Delivery Systems01:23

Ophthalmic Drug Delivery Systems

Ophthalmic drug delivery faces major limitations due to poor absorption across the corneal membrane. This process is primarily driven by diffusion and is influenced by two main factors: the physicochemical properties of the drug and tear drainage. Most ophthalmic drugs, such as pilocarpine, epinephrine, atropine, and local anesthetics, are weak bases. They are typically formulated at an acidic pH to enhance chemical stability. However, this leads to high ionization, reducing their ability to...

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Related Experiment Video

Updated: May 8, 2026

Glaucoma-inducing Procedure in an In Vivo Rat Model and Whole-mount Retina Preparation
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Published on: March 12, 2016

Primary lens extraction for glaucoma management: A review article.

Tarek M Eid1

  • 1Tanta University, Egypt.

Saudi Journal of Ophthalmology : Official Journal of the Saudi Ophthalmological Society
|August 21, 2013
PubMed
Summary

Primary lens extraction is a viable surgical option for glaucoma, particularly effective in primary angle closure glaucoma (PACG) for reducing intraocular pressure (IOP) and preventing attacks. Its effectiveness in primary open-angle glaucoma (POAG) is less predictable.

Keywords:
Angle closure glaucomaIntraocular pressureOpen-angle glaucomaPrimary lens extractionSurgical management

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Last Updated: May 8, 2026

Glaucoma-inducing Procedure in an In Vivo Rat Model and Whole-mount Retina Preparation
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Published on: March 12, 2016

Iris Fixation via External Pentagram Suturing
05:22

Iris Fixation via External Pentagram Suturing

Published on: May 5, 2022

Area of Science:

  • Ophthalmology
  • Glaucoma Management
  • Surgical Innovation

Background:

  • Primary lens extraction is increasingly recognized as a surgical alternative for glaucoma management.
  • Advances in phacoemulsification and intraocular lenses enhance safety and visual recovery.
  • This approach offers potential benefits like reduced intraocular pressure (IOP), deepened anterior chamber, and widened filtration angles.

Purpose of the Study:

  • To evaluate the efficacy of primary lens extraction as a standalone surgical treatment for different types of glaucoma.
  • To compare the intraocular pressure (IOP)-lowering effects in primary open-angle glaucoma (POAG) versus primary angle closure glaucoma (PACG).
  • To explore the role of lens extraction in managing acute and chronic PACG and its comparison with traditional glaucoma surgeries.

Main Methods:

  • Review of current literature and clinical acceptance of primary lens extraction for glaucoma.
  • Analysis of IOP reduction trends in POAG and PACG patients undergoing lens extraction.
  • Comparison of outcomes between lens extraction and other glaucoma surgical interventions.

Main Results:

  • Lens extraction provides a mild, less predictable IOP reduction in POAG, which may not be sustained.
  • Lens extraction consistently achieves greater IOP reduction in PACG compared to POAG.
  • In acute PACG, lens extraction reduces recurrence risk, deepens the anterior chamber, and widens the angle, mitigating risks of synechiae and chronic PACG.

Conclusions:

  • Primary lens extraction is a potentially preferable option over incisional surgery for mild to moderate PACG with appositional angle closure.
  • The decision for primary lens extraction requires individualization, considering patient factors, surgeon expertise, glaucoma status, and lens choice.
  • While beneficial for PACG, the IOP-lowering effect in POAG may be insufficient for adequate control.