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Updated: May 8, 2026

An Experimental Human DIEP Flap Model to Investigate Preservation Strategies for Vascularized Composite Allografts and Free Flaps
Published on: December 5, 2025
Flap prefabrication using high-density porous polyethylene in an animal model – an experimental study
Łukasz Krakowxzyk1, Adam Maciejewski, Cezary Szymczyk
1Department of Oncological and Reconstructive Surgery, Center of Oncology, Institute of Oncology Memorial Maria Sklodowska-Curie in Gliwice, Gliwice, Poland. lukaszkrakowczyk@wp.pl
Background:
The search for new surgical flap techniques and modifications of already existing ones is gaining increasing popularity. Progress in flap designing and harvesting have improved the functional and aesthetic results, especially in head and neck reconstruction.
Material/Methods:
Ten pigs were used in this study. In the first operation, high-density porous polyethylene prefabrication was performed bilaterally in all pigs. After 8 weeks, each prefabricated complex was explored, resected, and macroscopically evaluated.
Results:
All of 20 prefabricated flaps survived. No serious surgical complications were observed. In 2 cases there was chronic inflammation and in 4 cases there was instability of the implant.
Conclusions:
After this experimental study, we believe that the use of high-density porous polyethylene in flap prefabrication may be a good option for reconstruction of 3-dimensional defects, especially in patients with limited donor tissues.

