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Updated: May 8, 2026

Optical Trapping of Nanoparticles

Optical Trapping of Nanoparticles

Published on: January 15, 2013

Enhanced Raman signals from switchable nanoparticle probes.

Phyllis F Xu¹, Ju Hun Lee, Ke Ma

¹Department of Nanoengineering and Materials Science Program, University of California-San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA.

Chemical Communications (Cambridge, England)

|August 22, 2013

Summary

We developed a DNA nanostructure that controls nanoparticle spacing, significantly altering the surface-enhanced Raman scattering (SERS) signal. This DNA-based switchable nanodumbbell offers new possibilities for SERS sensing applications.

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Area of Science:

Nanotechnology
Biomolecular Engineering
Spectroscopy

Background:

Surface-enhanced Raman scattering (SERS) is a powerful technique for detecting molecules at low concentrations.
Controlling nanoparticle inter距离 is crucial for optimizing SERS signals.
DNA nanotechnology offers precise control over nanoscale structures.

Purpose of the Study:

To design and demonstrate a DNA-based nanostructure capable of modulating the distance between nanoparticles.
To investigate the impact of this distance modulation on SERS signals.
To establish a switchable nanodumbbell platform for enhanced SERS detection.

Main Methods:

Construction of a DNA-based nanodumbbell linker.
Assembly of gold-silver core-shell nanoparticles onto the DNA linker.

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Optical Trapping of Nanoparticles

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Characterization of the nanodumbbell structure using electron microscopy.

Measurement of SERS signals with varying interparticle distances.

Main Results:

The DNA nanodumbbell successfully modulated the interparticle distance between gold-silver nanoparticles.
Significant changes in SERS intensity were observed correlating with distance modulation.
The conformationally switchable nature of the DNA linker was confirmed.

Conclusions:

A novel DNA-based switchable nanodumbbell was successfully fabricated.
This platform enables precise control over nanoparticle spacing for SERS signal modulation.
The developed nanodumbbell holds potential for advanced SERS-based sensing applications.