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Clarithromycin-induced haemorrhagic colitis
Ryosuke Miyauchi1, Kensuke Kinoshita, Yasuharu Tokuda
1Department of General Internal Medicine, Mito Kyodo General Hospital, University of Tsukuba, Mito, Ibaraki, Japan.
BMJ Case Reports
|August 22, 2013
Summary
Antibiotic-associated colitis can be caused by Klebsiella oxytoca, particularly after clarithromycin use. This case highlights the risk of Klebsiella oxytoca-induced haemorrhagic colitis in patients treated with clarithromycin.
Area of Science:
- Gastroenterology
- Infectious Diseases
- Microbiology
Background:
- Antibiotic-associated colitis is a known complication of certain antibiotics.
- Klebsiella oxytoca has been previously implicated in haemorrhagic colitis, particularly with ampicillin use.
Observation:
- A 67-year-old female with diabetes presented with symptoms of mucobloody diarrhea and abdominal pain.
- Stool cultures confirmed the presence of Klebsiella oxytoca.
- Colonoscopy revealed characteristic findings of haemorrhagic colitis.
Findings:
- The patient had recently completed a course of oral clarithromycin for an upper respiratory tract infection.
- This case demonstrates a link between clarithromycin and Klebsiella oxytoca-induced haemorrhagic colitis.
- The patient recovered with conservative management.
Implications:
- Clinicians should be vigilant for gastrointestinal symptoms in patients prescribed clarithromycin.
- Klebsiella oxytoca should be considered as a potential cause of antibiotic-associated haemorrhagic colitis, even with newer antibiotics like clarithromycin.
- This finding expands the spectrum of antibiotics associated with Klebsiella oxytoca-induced colitis.
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