[Drug interactions in combination pharmacotherapy]

Data are summarized on the interaction of drugs when several of them are used simultaneously. A scheme is presented based on the principle of location of the drug in the body, correspondence of the preplanned effect and actual efficacy, pharmaceutic, pharmacokinetic, pharmacodynamic phases. These findings allow to objectivize and plan rational, effective and safe treatment. Evaluation of interaction of drugs used simultaneously permits to organize a qualitatively optimal and an economically advantageous variant of pharmacotherapy.