[Acromegaly and pregnancy]

Pregnancy in women with acromegaly is very rare. The introduction of dopaminergic treatment revealed new possibilities for conception. Four acromegalic women who conceived during a course of bromcryptin treatment and after an unsuccessful transsphenoidal adenectomy are presented. Two of the women have given birth to a normal child, the third woman aborted willfully and the delivery of the fourth woman is forthcoming. Bromcyptin was given during the whole course of pregnancy in progressively increasing doses up to 15 mg daily according to the increased levels of the somatotrophic hormone (STH). The action of bromcryptin on some hormones of the mother and the child is discussed. The mother's serum STH level increased in the course of the pregnancy progressively despite the treatment and fell after the delivery while the child's STH levels were normal.