[Acromegaly and pregnancy].

Area of Science:

• Endocrinology
• Reproductive Medicine
• Obstetrics

Background:

• Acromegaly, a rare endocrine disorder, presents significant challenges for pregnancy.
• Historically, conception in acromegalic women was infrequent and associated with high risks.

Observation:

• This case series presents four women with acromegaly who conceived while undergoing bromocriptine treatment.
• These women had previously undergone unsuccessful transsphenoidal adenectomy for their condition.

Findings:

• Two women delivered healthy infants, one woman voluntarily terminated her pregnancy, and the fourth woman's delivery was pending.
• Bromocriptine was administered throughout pregnancy, with dosage adjusted based on somatotropic hormone (STH) levels.
• Maternal STH levels increased during pregnancy despite treatment, normalizing postpartum, while infant STH levels remained normal.

Implications:

• Dopaminergic agonists like bromocriptine offer a viable therapeutic option for inducing conception in acromegalic women.
• Management requires careful monitoring of maternal and fetal hormone levels throughout gestation.
• Further research is warranted to fully elucidate the long-term effects of bromocriptine in pregnant acromegalic patients.