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The effect of topical doxycycline on corneal neovascularization

Vesna Jovanovic¹, Ljubisa Nikolic

¹Faculty of Medical Dentistry, University of Belgrade , Dr Subotica 8, Belgarde , Serbia.

Current Eye Research

|August 23, 2013

Abstract

Purpose:

To examine the effect of topical doxycycline on human corneal neovascularization (CONV).

Materials And Methods:

Six eyes of six patients with CONV received topical 1% doxycycline four times per day for three weeks and monitored for a total of one year. Ophthalmic evaluations included visual acuity, tonometry, slit-lamp examination, conjunctival swabs, quantification of CONV and photography.

Results:

CONV either disappeared or was attenuated, shortened and less dense in five of six patients. There were no adverse effects.

Conclusion:

Topical doxycycline was effective in reducing CONV and healing of the ocular surface.

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