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Intratumoral anti-CTLA-4 therapy: enhancing efficacy while avoiding toxicity

Aurélien Marabelle1, Holbrook Kohrt, Ronald Levy

  • 1Authors' Affiliations: Department of Medicine, Division of Oncology, Stanford University, Stanford, California; and Centre de Recherche en Cancérologie de Lyon (CRCL), UMR INSERM U1052 CNRS 5286, Centre Léon Bérard, Université de Lyon, Lyon, France.

Clinical Cancer Research : an Official Journal of the American Association for Cancer Research
|August 23, 2013
PubMed

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Tumor Immunotherapy

Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
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Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against specific...