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Yeast Signaling

Yeast Signaling

Yeasts are single-celled organisms, but unlike bacteria, they are eukaryotes (cells with a nucleus). Cell signaling in yeast is similar to signaling in other eukaryotic cells. A ligand, such as a protein or a small molecule released from a yeast cell, attaches to a receptor on the cell surface. The binding stimulates second-messenger kinases to activate or inactivate transcription factors that further regulate gene expression. Many of the yeast intracellular signaling cascades have similar...

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Updated: May 8, 2026

Microscopy of Fission Yeast Sexual Lifecycle

Microscopy of Fission Yeast Sexual Lifecycle

Published on: March 9, 2016

A microfluidic synchronizer for fission yeast cells.

Yuan Tian¹, Chunxiong Luo, Qi Ouyang

¹Center for Microfluidic and Nanotechnology, The State Key Laboratory for Artificial Microstructures and Mesoscopic Physics, School of Physics, Peking University, Beijing, 100871 China. pkuluocx@pku.edu.cn qi@pku.edu.cn.

|August 23, 2013

Summary

This summary is machine-generated.

This study introduces a novel baby machine for synchronizing fission yeast cell cycles without artifacts. The device immobilizes mother cells, collecting synchronized daughter cells for improved cell biology research.

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Last Updated: May 8, 2026

Microscopy of Fission Yeast Sexual Lifecycle

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Published on: March 9, 2016

Examination of Mitotic and Meiotic Fission Yeast Nuclear Dynamics by Fluorescence Live-cell Microscopy

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Manipulation and Analysis of Cell Cycle-Dependent Processes in Budding Yeast

Manipulation and Analysis of Cell Cycle-Dependent Processes in Budding Yeast

Published on: September 26, 2025

Area of Science:

Cell Biology
Biotechnology
Microfluidics

Background:

Cell cycle synchronization is crucial for biological studies.
Existing synchronization methods often introduce artifacts or metabolic stress.
Microfluidic devices offer potential for artifact-free cell synchronization.

Purpose of the Study:

To develop a novel, artifact-free baby machine for synchronizing fission yeast (Schizosaccharomyces pombe).
To address the challenge of immobilizing rod-shaped cells in microfluidic devices.
To create an integrated on-chip tool for cell biology research.

Main Methods:

Development of a microfluidic baby machine designed for fission yeast.
Utilizing a unique immobilization strategy to fix mother cells.
Incorporating a polymer-based cell screener for automated collection.
Evaluating device performance and working principles.

Main Results:

Successfully produced synchronous populations of fission yeast cells.
Demonstrated an effective method for immobilizing rod-shaped mother cells.
The integrated cell screener facilitated convenient collection and downstream assays.
Analyzed the device's working details and performance metrics.

Conclusions:

The novel baby machine provides an artifact-free method for fission yeast synchronization.
This device overcomes previous limitations in immobilizing rod-shaped cells.
The integrated system offers a valuable new tool for on-chip cell biology studies.