Related Experiment Video
Updated: May 8, 2026

A Reporter Assay to Analyze Intronic microRNA Maturation in Mammalian Cells
Published on: June 16, 2022
Latency locus complements MicroRNA 155 deficiency in vivo
Sang-Hoon Sin1, Yong Baek Kim, Dirk P Dittmer
1Department of Microbiology and Immunology, Program in Global Oncology, Lineberger Comprehensive Cancer Center, and Center for AIDS Research, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.
None:
MicroRNA-155 (miR-155) is expressed in many cancers. It also executes evolutionary conserved functions in normal B cell development. We show that the Kaposi's sarcoma-associated herpesvirus (KSHV) latency locus, which contains an ortholog of miR-155, miR-K12-11, complements B cell deficiencies in miR-155 knockout mice. Germinal center (GC) formation was rescued in spleen, lymph node, and Peyer's patches. Immunoglobulin levels were restored. This demonstrates that KSHV can complement the normal, physiological function of miR-155.
More Related Videos
Related Concept Videos
MicroRNAs
MicroRNAs
MicroRNAs
lncRNA - Long Non-coding RNAs
Non-LTR Retrotransposons

