Eosinophilic infiltrates in epidermolysis bullosa

Inherited epidermolysis bullosa encompasses many subsets of diseases, distinguished by skin fragility and blister formation after minor trauma. Histologically, epidermolysis bullosa usually presents as bullae without inflammatory cells. We present four cases of epidermolysis bullosa, including examples of epidermolytic, junctional, and dermolytic types that have eosinophilic infiltrates. These cases do not represent subtypes of epidermolysis bullosa, but simply the influx of eosinophils in neonatally manifested disease. Several hypotheses for the presence of these eosinophils are presented.