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Related Experiment Video

Updated: May 8, 2026

Production of Nurr-1 Specific Polyclonal Antibodies Free of Cross-reactivity Against Its Close Homologs, Nor1 and Nur77

Production of Nurr-1 Specific Polyclonal Antibodies Free of Cross-reactivity Against Its Close Homologs, Nor1 and Nur77

Published on: August 17, 2015

NMNATs, evolutionarily conserved neuronal maintenance factors.

Yousuf O Ali¹, David Li-Kroeger, Hugo J Bellen

¹The Cain Foundation Laboratories, Texas Children's Hospital, Houston, TX 77030, USA; Jan and Dan Duncan Neurological Research Institute at Texas Children's Hospital, Houston, TX 77030, USA; Department of Pediatrics, Baylor College of Medicine, Houston, TX 77030, USA.

Trends in Neurosciences

|August 24, 2013

Summary

This summary is machine-generated.

Nicotinamide adenine dinucleotide (NAD+) biosynthesis enzymes, nicotinamide mononucleotide adenylyl transferases (NMNATs), actively maintain neuronal health. These enzymes protect neurons from stress and aging, preserving brain function throughout life.

Keywords:

NAD NMNAT axonopathy chaperone neurodegeneration neuronal maintenance proteinopathies synapse

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Published on: March 17, 2014

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Last Updated: May 8, 2026

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Genetic Manipulation of Cerebellar Granule Neurons In Vitro and In Vivo to Study Neuronal Morphology and Migration

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Published on: March 17, 2014

Area of Science:

Neuroscience
Cellular biology
Biochemistry

Background:

Neuronal homeostasis is crucial for proper brain function.
Neuronal activity, injury, and aging can cause dysfunction and degeneration.
Organisms possess active mechanisms to maintain neuronal health throughout life.

Purpose of the Study:

To review the neuronal maintenance and protective functions of nicotinamide mononucleotide adenylyl transferases (NMNATs).
To highlight the diverse mechanisms by which NMNATs protect neurons.
To explore functions dependent or independent of NMNAT catalytic activity.

Main Methods:

Literature review of recent studies on NMNATs in neuronal maintenance.
Analysis of evidence for NMNAT protective functions in various contexts.
Summary of data supporting NMNATs' role in preserving neuronal integrity.

Main Results:

NMNATs play a key role in neuronal maintenance and protection.
NMNATs employ multiple mechanisms to safeguard neurons.
Some NMNAT functions require catalytic activity, while others are independent.

Conclusions:

NMNATs are vital for preserving neuronal integrity and function.
Further research is needed to fully understand how NMNATs maintain neuronal health.
NMNATs represent a significant target for understanding and promoting healthy aging in the nervous system.