Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Renal transplantation in infants.

J S Najarian1, D J Frey, A J Matas

  • 1Department of Surgery, University of Minnesota Medical School, Minneapolis.

Annals of Surgery
|September 1, 1990
PubMed
Summary

Renal transplantation in infants shows excellent survival rates comparable to older children. Successful kidney transplants improve infant growth and development, highlighting the importance of living donors.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The effect of peri-transplant plasmapheresis in the prevention of recurrent FSGS.

Pediatric transplantation·2018
Same author

Genome-wide association study identifies the common variants in CYP3A4 and CYP3A5 responsible for variation in tacrolimus trough concentration in Caucasian kidney transplant recipients.

The pharmacogenomics journal·2017
Same author

Renal Consequences of Diabetes After Kidney Donation.

American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons·2017
Same author

The impact of recipient BKV shedding before transplant on BKV viruria, DNAemia, and nephropathy post-transplant: A prospective study.

Pediatric transplantation·2017
Same author

The Living Donor Collective: A Scientific Registry for Living Donors.

American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons·2017
Same author

Successful Renal Transplantation in Small Children With a Completely Thrombosed Inferior Vena Cava.

American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons·2017

Area of Science:

  • Pediatric Nephrology
  • Transplant Surgery
  • Immunology

Background:

  • Infant renal transplantation timing remains a debated topic.
  • Early kidney failure in infants necessitates timely intervention.
  • Congenital anomalies like hypoplasia and obstructive uropathy are leading causes of renal failure in this age group.

Purpose of the Study:

  • To evaluate the outcomes of renal transplantation in infants under two years of age.
  • To compare graft and patient survival rates in different infant age groups and with older children.
  • To identify factors influencing graft survival and patient outcomes in pediatric kidney transplantation.

Main Methods:

  • Retrospective analysis of 79 renal transplants performed between 1965 and 1989 in 75 infants.

Related Experiment Videos

  • Categorization of infants by age (≤12 months vs. 12-24 months), donor type (living related, living unrelated, cadaver), and transplant type (primary, retransplant).
  • Intra-abdominal transplant technique with distal aortic anastomosis was employed.

    • Main Results:

    • Overall patient survival is 91% at 5 years, and graft survival is 73% at 5 years.
    • Cyclosporine immunosuppression achieved 100% patient survival and 82% graft survival at 5 years.
    • No significant difference in outcomes was observed between infants ≤12 months and those 12-24 months, or compared to older children.

    Conclusions:

    • Infant renal transplantation yields excellent short- and long-term survival rates comparable to older children.
    • Successful transplantation leads to improved growth, head circumference, and development in infants.
    • Living donor kidney transplantation is recommended whenever feasible for optimal outcomes in pediatric patients.