Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Video

Updated: May 8, 2026

Optical Trapping of Nanoparticles
13:39

Optical Trapping of Nanoparticles

Published on: January 15, 2013

Sensing nanoparticles using a double nanohole optical trap.

Abhay Kotnala1, Damon DePaoli, Reuven Gordon

  • 1University of Victoria, Electrical and Computer Engineering, Victoria, Canada. rgordon@uvic.ca.

Lab on a Chip
|August 24, 2013
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Deterministic, dynamically reconfigurable single quantum emitters enabled by tip-enhanced nano-optical trapping spectroscopy.

Nature communications·2026
Same author

Label-free optical observation of disordered-to-ordered transitions in single intrinsically disordered proteins.

Npj biosensing·2026
Same author

Small Molecule Activators of Protein Phosphatase 2A Exert Global Stabilizing Effects on the Scaffold PR65.

JACS Au·2026
Same author

Isolation and Purification-Free Digital Single-Small Extracellular Vesicle Biosensing with Scalable Plasmonic Arrays.

bioRxiv : the preprint server for biology·2026
Same author

Small Molecule Activator of Phosphatase PP2A Remodels Scaffold PR65 Structural Dynamics To Promote Holoenzyme Assembly.

JACS Au·2026
Same author

Label-Free Single-Molecule Conalbumin Analysis.

Micromachines·2026
Same journal

Microfluidic rare cell analysis beyond counting: workflow design from enrichment to multi-omics.

Lab on a chip·2026
Same journal

A sperm racetrack to separate sperm by swim speed.

Lab on a chip·2026
Same journal

Controlled encapsulation and droplet size prediction in two-step microfluidic double emulsions.

Lab on a chip·2026
Same journal

A particulate blood-mimicking fluid with physiological biconcave geometry for microscale hemorheology.

Lab on a chip·2026
Same journal

Multicellular sensor arrays fabricated by capillary stamping for pattern-based odor discrimination.

Lab on a chip·2026
Same journal

A real-time microfluidic surveillance system for multiplex detection of heavy metal contamination in wastewater.

Lab on a chip·2026
See all related articles

We developed a double nanohole optical trap to measure nanoparticle size and concentration. This method precisely quantifies particles, even in complex mixtures, with applications in sensing and studying virus populations.

Area of Science:

  • Nanotechnology
  • Optical Physics
  • Analytical Chemistry

Background:

  • Accurate nanoparticle characterization is crucial for various scientific fields.
  • Existing methods often struggle with heterogeneous solutions or wide concentration ranges.

Purpose of the Study:

  • To develop and validate a double nanohole (DNH) optical trap for quantifying nanoparticle size and concentration.
  • To demonstrate the DNH trap's capability for selective sizing and analysis of individual particles within mixtures.

Main Methods:

  • Utilizing a double nanohole (DNH) optical trap setup.
  • Analyzing the time-to-trap dependence on nanosphere size and concentration.
  • Investigating trapping event characteristics and their relation to particle properties like refractive index.

More Related Videos

Plasmonic Trapping and Release of Nanoparticles in a Monitoring Environment
09:13

Plasmonic Trapping and Release of Nanoparticles in a Monitoring Environment

Published on: April 4, 2017

Monitoring Conformational Dynamics of Single Unmodified Proteins using Plasmonic Nanotweezers
09:33

Monitoring Conformational Dynamics of Single Unmodified Proteins using Plasmonic Nanotweezers

Published on: March 21, 2025

Related Experiment Videos

Last Updated: May 8, 2026

Optical Trapping of Nanoparticles
13:39

Optical Trapping of Nanoparticles

Published on: January 15, 2013

Plasmonic Trapping and Release of Nanoparticles in a Monitoring Environment
09:13

Plasmonic Trapping and Release of Nanoparticles in a Monitoring Environment

Published on: April 4, 2017

Monitoring Conformational Dynamics of Single Unmodified Proteins using Plasmonic Nanotweezers
09:33

Monitoring Conformational Dynamics of Single Unmodified Proteins using Plasmonic Nanotweezers

Published on: March 21, 2025

Main Results:

  • Established a linear relationship between time-to-trap and nanosphere size.
  • Observed a -2/3 power dependence of time-to-trap on nanosphere concentration.
  • Demonstrated size-specificity within a few nanometers for selective quantification.
  • Showed that trapping indication scales with the Clausius-Mossotti factor for different particle types.

Conclusions:

  • The DNH optical trap offers a versatile platform for nanoparticle quantification across various sizes and concentrations.
  • This technique enables selective analysis of single particle sizes in heterogeneous solutions.
  • Potential applications include precise monitoring of virus populations and other complex nanoscale systems.