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Related Concept Videos

Ophthalmic Drug Delivery Systems01:23

Ophthalmic Drug Delivery Systems

Ophthalmic drug delivery faces major limitations due to poor absorption across the corneal membrane. This process is primarily driven by diffusion and is influenced by two main factors: the physicochemical properties of the drug and tear drainage. Most ophthalmic drugs, such as pilocarpine, epinephrine, atropine, and local anesthetics, are weak bases. They are typically formulated at an acidic pH to enhance chemical stability. However, this leads to high ionization, reducing their ability to...
Drug Product Stability01:16

Drug Product Stability

The long-term stability of drug products is critical to ensuring their quality, safety, and effectiveness over time. Stability directly influences a product's ability to maintain its intended characteristics, ensuring it performs as expected during its intended shelf life. Key attributes such as drug potency, impurities, dissolution, and other physicochemical measures of performance are tested to assess stability. These parameters indicate how well the product retains its quality over time and...

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Related Experiment Video

Updated: May 8, 2026

A Novel Method to Determine the Longitudinal Antibacterial Activity of Drug-Eluting Materials
06:18

A Novel Method to Determine the Longitudinal Antibacterial Activity of Drug-Eluting Materials

Published on: March 3, 2023

Testing the long term stability of vancomycin ophthalmic solution.

Christine McLellan1, Van Ngo, Sophia Pasedis

  • 1Massachusetts Eye and Ear Infirmary, Boston, Massachusetts.

International Journal of Pharmaceutical Compounding
|August 24, 2013
PubMed
Summary

Vancomycin ophthalmic solution for artificial cornea patients remains stable for at least 60 days at room temperature. This extended stability for vancomycin eye drops may improve patient adherence and convenience.

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Last Updated: May 8, 2026

A Novel Method to Determine the Longitudinal Antibacterial Activity of Drug-Eluting Materials
06:18

A Novel Method to Determine the Longitudinal Antibacterial Activity of Drug-Eluting Materials

Published on: March 3, 2023

Area of Science:

  • Ophthalmology
  • Pharmaceutical Sciences
  • Drug Stability

Background:

  • Patients with keratoprostheses require lifelong prophylactic vancomycin ophthalmic solution to prevent infection.
  • Current storage guidelines for vancomycin eye drops may limit patient adherence and satisfaction.

Purpose of the Study:

  • To determine the room temperature stability of vancomycin ophthalmic solution beyond current recommendations.
  • To evaluate the potential for extending the beyond-use dating (BUD) of vancomycin eye drops.

Main Methods:

  • Vancomycin 14-mg/mL ophthalmic solutions compounded with 0.005% benzalkonium chloride were prepared.
  • Samples were tested for potency using high-performance liquid chromatography (HPLC) at various time points.
  • Stability was assessed at room temperature and under frozen conditions.

Main Results:

  • Vancomycin ophthalmic solution retained potency for at least 60 days at room temperature.
  • The solution remained stable for 6 months when frozen.
  • Potency was maintained throughout the extended study period.

Conclusions:

  • Vancomycin ophthalmic solution demonstrates adequate stability at room temperature for at least 60 days.
  • Extending the beyond-use dating of vancomycin eye drops could enhance patient convenience and adherence.
  • Relaxed storage requirements may reduce costs associated with medication management for keratoprosthesis patients.