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Updated: May 8, 2026

An In Vivo Estrogen Deficiency Mouse Model for Screening Exogenous Estrogen Treatments of Cardiovascular Dysfunction After Menopause
Published on: August 13, 2019
Low-dose estrogen and drospirenone combination: effects on metabolism and endothelial function in postmenopausal
P De Franciscis1, G Mainini, D Labriola
1Department of Obstetrics, Gynaecology and Reproductive Sciences, Second University of Naples, Naples, Italy.
Purpose:
Metabolic syndrome and endothelial dysfunction play a relevant role in the cardiovascular risk in post-menopause. The aim of the study was to assess the effects of a low-dose hemihydrate estradiol and drospirenone combination on cardiovascular risk parameters in postmenopausal women with metabolic syndrome.
Materials And Methods:
Twenty-eight healthy women (group A) and 28 women with metabolic syndrome (group B) were treated with hemihydrate estradiol one mg + drospirenone two mg. At recruitment and after six months, clinical and laboratory parameters of metabolic syndrome were evaluated. Endothelial function was assessed measuring the flow-mediated dilatation of the brachial artery and the intima-media thickness of the common carotid artery.
Results:
After six months an overall improvement of metabolism was observed in both groups reaching statistical significance for triglycerides, total cholesterolemia, and systolic pressure in group B. A trend to lower baseline flow-mediated dilatation was also found in group B.
Conclusions:
Drospirenone improves cardiovascular risk factors and does not impair endothelial function in menopausal women with metabolic syndrome.
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