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Related Experiment Video

Updated: May 8, 2026

Rating L-DOPA-Induced Dyskinesias in the Unilaterally 6-OHDA-Lesioned Rat Model of Parkinson's Disease

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Striatal denervation pattern predicts levodopa effects on sequence learning in Parkinson's disease.

Y Kwak¹, N I Bohnen, M L T M Müller

¹Neuroscience Program, University of Michigan, Ann Arbor, USA. youngbin.kwak@duke.edu

Journal of Motor Behavior

|August 27, 2013

Summary

Parkinson's disease patients with more intact dopamine pathways in the putamen experienced greater sequence learning impairments when taking levodopa. The pattern of brain cell loss, not just the amount, predicts medication response in Parkinson's.

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Last Updated: May 8, 2026

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Murine Model for Parkinson's Disease: from 6-OH Dopamine Lesion to Behavioral Test

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Published on: January 15, 2010

Area of Science:

Neuroscience
Neurology
Movement Disorders

Background:

Parkinson's disease (PD) is characterized by progressive neurodegeneration, primarily affecting dopaminergic neurons in the nigrostriatal pathway.
In mild to moderate PD, denervation is typically more pronounced in the posterodorsal striatum, with relative sparing of the anteroventral striatum.
Dopaminergic medications, like levodopa, can potentially disrupt the function of these relatively preserved anteroventral striatal regions.

Purpose of the Study:

To investigate the relationship between the regional pattern of striatal denervation and medication-associated effects on motor sequence learning in Parkinson's disease.
To determine if the spatial distribution of nigrostriatal dopaminergic denervation influences sequence learning performance on and off dopaminergic medication.

Main Methods:

Eighteen patients with mild to moderate Parkinson's disease were assessed.
Motor sequence learning tasks were performed both with and without levodopa medication.
Nigrostriatal denervation was quantified using (11)C-dihydrotetrabenazine positron emission tomography (PET) scans.

Main Results:

Patients exhibiting greater preservation of the putamen (a striatal region) were more susceptible to sequence learning impairments when treated with levodopa.
The ratio of dopaminergic denervation between the anterior and posterior dorsal putamen was a significant predictor of the magnitude of sequence learning differences observed on versus off levodopa.
These findings highlight the importance of the spatial topography of neurodegeneration.

Conclusions:

The specific spatial pattern of nigrostriatal dopaminergic denervation in Parkinson's disease is a critical factor in predicting responsiveness to dopaminergic medication for motor sequence learning.
Understanding regional denervation patterns may inform personalized treatment strategies for Parkinson's disease patients.