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Related Concept Videos

Glaucoma: Overview01:25

Glaucoma: Overview

Glaucoma is an eye condition characterized by increased intraocular pressure that damages the retina and optic nerve, leading to irreversible blindness if left untreated. The human eye has various components, including the cornea, iris, pupil, lens, and optic nerve. Aqueous humor is secreted by the epithelium of the ciliary body in the posterior chamber and flows through the trabecular meshwork and canal of Schlemm, maintaining normal intraocular pressure. The trabecular meshwork and the canal...
Open Angle Glaucoma: Treatment01:27

Open Angle Glaucoma: Treatment

In open-angle glaucoma, the iridocorneal angle remains open, but the trabecular meshwork becomes stiff, slowing down the outflow of aqueous humor. This causes a buildup of aqueous humor in the anterior chamber, leading to a sudden increase in intraocular pressure. The treatment for open-angle glaucoma focuses on reducing the elevated intraocular pressure by either decreasing the secretion of aqueous humor or increasing its outflow.
Drugs such as carbonic anhydrase inhibitors, α2- and...
Angle Closure Glaucoma: Treatment01:28

Angle Closure Glaucoma: Treatment

Angle-closure glaucoma, or closed-angle glaucoma, is an eye condition where the iris bulges out and blocks the iridocorneal angle, resulting in a buildup of aqueous humor and increased intraocular pressure. Immediate medical attention is necessary due to the sudden onset of symptoms. The treatment for angle-closure glaucoma includes short-term and long-term approaches. Short-term treatment involves using eye drops like pilocarpine to lower intraocular pressure by increasing aqueous humor...

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Related Experiment Video

Updated: May 8, 2026

In vivo Structural Assessments of Ocular Disease in Rodent Models using Optical Coherence Tomography
07:44

In vivo Structural Assessments of Ocular Disease in Rodent Models using Optical Coherence Tomography

Published on: July 24, 2020

Improved visualization of deep ocular structures in glaucoma using high penetration optical coherence tomography.

Kaweh Mansouri1, Brenda Nuyen, Robert N Weinreb

  • 1Hamilton Glaucoma Center and Department of Ophthalmology, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093-0946, USA.

Expert Review of Medical Devices
|August 27, 2013
PubMed
Summary

Optical coherence tomography (OCT) advances glaucoma research. Swept-source (SS)-OCT offers superior visualization of the lamina cribrosa (LC) and choroid for understanding glaucoma pathogenesis.

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Area of Science:

  • Ophthalmology
  • Medical Imaging
  • Neuroscience

Background:

  • Glaucoma is a leading cause of irreversible blindness.
  • The lamina cribrosa (LC) is implicated in glaucoma pathogenesis.
  • Current imaging methods have limitations in visualizing deep ocular structures.

Purpose of the Study:

  • To review current knowledge of the LC.
  • To evaluate spectral domain OCT (SD-OCT) and enhanced depth imaging OCT (EDI-OCT) findings.
  • To present experience with prototype swept-source OCT (SS-OCT) for LC and choroid visualization.

Main Methods:

  • Review of current literature on LC and OCT imaging modalities.
  • Analysis of findings from SD-OCT and EDI-OCT trials.
  • Utilizing a prototype SS-OCT (1050 nm) for in vivo imaging of the LC and choroid.

Main Results:

  • SD-OCT and EDI-OCT provide insights but struggle with posterior laminar surface clarity.
  • SS-OCT, using longer wavelengths, enables in vivo imaging of the LC and choroid.
  • SS-OCT shows potential for quantifying choroidal changes and visualizing the entire LC.

Conclusions:

  • SS-OCT represents a significant advancement for imaging deep ocular structures.
  • Improved visualization of the LC and choroid with SS-OCT may enhance understanding of glaucoma.
  • Further research with SS-OCT is warranted to elucidate glaucoma pathogenesis.