Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Diabetes: Symptoms, Diagnosis, and Complications01:15

Diabetes: Symptoms, Diagnosis, and Complications

For most patients, experiencing several weeks of polyuria, polydipsia, fatigue, and significant weight loss may indicate the presence of diabetes. Furthermore, adults displaying the phenotypic appearance of type 2 diabetes (particularly those who are obese and not initially insulin-requiring), may have islet cell autoantibodies, suggesting autoimmune-mediated β cell destruction and a diagnosis of latent autoimmune diabetes of adults (LADA). The categorization of glucose homeostasis is based on...
Diabetes Mellitus: Type 2 and Gestational01:22

Diabetes Mellitus: Type 2 and Gestational

Type 2 diabetes, characterized by insulin resistance, arises when the insulin receptors on cells lose responsiveness to insulin, diminishing the cell's capacity to take up glucose, resulting in elevated blood glucose levels. To receive a diagnosis of Type 2 diabetes, a series of blood glucose tests are necessary to assess whether the blood glucose falls within normal parameters. If the result is out of the normal range, a patient may be diagnosed as prediabetic or diabetic, depending on the...
Psychoneuroimmunology: Diabetes and Cancer01:19

Psychoneuroimmunology: Diabetes and Cancer

Chronic stress has been linked to both the onset and progression of serious health conditions, including Type 2 diabetes and cancer. Type 2 diabetes, a widespread chronic illness, is closely associated with obesity and insulin resistance, both of which often worsen under stress. Studies indicate that men experiencing high levels of chronic stress face a 45% higher risk of developing diabetes compared to those with minimal stress. Stress triggers physiological responses that elevate blood...
Alzheimer Disease l: Introduction01:29

Alzheimer Disease l: Introduction

Alzheimer disease is a chronic, progressive, and irreversible neurodegenerative disorder and the most common cause of dementia in older adults. It leads to gradual neuronal loss, causing cognitive decline, behavioral changes, and loss of functional independence.Risk Factors and EtiologyThe disease is multifactorial. Age is the strongest risk factor, with prevalence doubling every 5 years after age 65. Genetic factors include mutations in genes such as APP, PSEN1, and PSEN2, which are associated...
Cognitive Development During Adulthood01:30

Cognitive Development During Adulthood

Cognitive development continues throughout adulthood, undergoing significant shifts across early, middle, and late stages. Individual transition occurs from adolescent idealism to pragmatic and adaptable thinking in early adulthood. During this period, individuals learn to integrate personal beliefs with the recognition that other perspectives are equally valid. Exposure to the complexities of modern society, diverse experiences, and higher education contribute to this adaptive thought process,...
Diabetes Mellitus: Overview and Type I Subtype01:22

Diabetes Mellitus: Overview and Type I Subtype

Diabetes mellitus is a chronic metabolic disorder characterized by high blood glucose levels due to inadequate insulin production, insulin resistance, or both. The condition affects millions worldwide and can significantly impact their health and quality of life.
Type 1 diabetes is an autoimmune disease in which the immune system mistakenly attacks and destroys the insulin-producing beta cells in the pancreas. As a result, the body is unable to produce sufficient insulin, and individuals with...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Sex Differences in Variability in General Intelligence: A New Look at the Old Question.

Perspectives on psychological science : a journal of the Association for Psychological Science·2015
Same author

Directional dominance on stature and cognition in diverse human populations.

Nature·2015
Same author

Improving Phenotypic Prediction by Combining Genetic and Epigenetic Associations.

American journal of human genetics·2015
Same author

A comparison of location of acute symptomatic vs. 'silent' small vessel lesions.

International journal of stroke : official journal of the International Stroke Society·2015
Same author

Rare and low-frequency variants and their association with plasma levels of fibrinogen, FVII, FVIII, and vWF.

Blood·2015
Same author

Coupled changes in brain white matter microstructure and fluid intelligence in later life.

The Journal of neuroscience : the official journal of the Society for Neuroscience·2015

Related Experiment Video

Updated: May 8, 2026

Osmotic Minipump Implantation for Increasing Glucose Concentration in Mouse Cerebrospinal Fluid
06:21

Osmotic Minipump Implantation for Increasing Glucose Concentration in Mouse Cerebrospinal Fluid

Published on: April 7, 2023

Diabetes and life-long cognitive ability.

René Mõttus1, Michelle Luciano, John M Starr

  • 1Centre for Cognitive Ageing and Cognitive Epidemiology, Department of Psychology, University of Edinburgh, UK. rene.mottus@ed.ac.uk

Journal of Psychosomatic Research
|August 27, 2013
PubMed
Summary

Older adults with diabetes show lower cognitive function due to lifelong cognitive differences, not diabetes-induced decline. This study explored the diabetes-cognition relationship, considering childhood cognitive ability.

Keywords:
CognitionCognitive abilityDiabetesHbA1cMetabolism

More Related Videos

Behavioral Assessment of Visual Function via Optomotor Response and Cognitive Function via Y-Maze in Diabetic Rats
07:41

Behavioral Assessment of Visual Function via Optomotor Response and Cognitive Function via Y-Maze in Diabetic Rats

Published on: October 23, 2020

A Zebrafish Model of Diabetes Mellitus and Metabolic Memory
10:03

A Zebrafish Model of Diabetes Mellitus and Metabolic Memory

Published on: February 28, 2013

Related Experiment Videos

Last Updated: May 8, 2026

Osmotic Minipump Implantation for Increasing Glucose Concentration in Mouse Cerebrospinal Fluid
06:21

Osmotic Minipump Implantation for Increasing Glucose Concentration in Mouse Cerebrospinal Fluid

Published on: April 7, 2023

Behavioral Assessment of Visual Function via Optomotor Response and Cognitive Function via Y-Maze in Diabetic Rats
07:41

Behavioral Assessment of Visual Function via Optomotor Response and Cognitive Function via Y-Maze in Diabetic Rats

Published on: October 23, 2020

A Zebrafish Model of Diabetes Mellitus and Metabolic Memory
10:03

A Zebrafish Model of Diabetes Mellitus and Metabolic Memory

Published on: February 28, 2013

Area of Science:

  • Neuroscience
  • Endocrinology
  • Gerontology

Background:

  • A common belief is that diabetes negatively impacts cognitive function.
  • Emerging research suggests some health conditions linked to cognitive decline may instead be associated with pre-existing cognitive abilities, indicating reverse causation.
  • Understanding the causal link between diabetes and cognition is crucial, especially in older populations.

Purpose of the Study:

  • To investigate the relationship between diabetes in older age and cognitive functioning in both childhood and later life.
  • To explore potential reverse causation in the diabetes-cognition association.

Main Methods:

  • Utilized data from the Lothian Birth Cohort 1936, including 1017 participants.
  • Compared general cognitive ability scores at ages 11 and 70 between individuals with and without diabetes at age 70.
  • Determined diabetes status using self-reports and HbA1c levels.

Main Results:

  • Individuals with diabetes exhibited lower mean cognitive ability at both age 11 and age 70 compared to non-diabetic individuals.
  • The effect size for cognitive ability difference was consistent across both age groups (Cohen's d≈0.32).
  • After adjusting for childhood cognitive ability, diabetes status was not significantly associated with cognitive ability at age 70. Factors like BMI and cholesterol partially explained the link between childhood cognition and later-life diabetes.

Conclusions:

  • The observed association between diabetes and poorer cognitive ability in old age in this cohort is attributable to lifelong lower cognitive ability in individuals with diabetes.
  • The findings suggest that diabetes does not impair cognitive functioning but rather shares common antecedents with lower cognitive ability.