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A quantitative method for evaluating local perfusion using indocyanine green fluorescence imaging.

Hiroaki Terasaki1, Yoshinori Inoue, Norihide Sugano

  • 1Department of Vascular and Applied Surgery, Tokyo Medical and Dental University, Graduate School, Tokyo, Japan.

Annals of Vascular Surgery
|August 27, 2013
PubMed
Summary
This summary is machine-generated.

Indocyanine green fluorescence imaging (ICG-FI) offers a new, non-contact method to quantitatively assess peripheral arterial disease and lower limb ischemia. This safe and fast technique aids in evaluating tissue perfusion, especially in critical cases.

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Area of Science:

  • Vascular Medicine
  • Medical Imaging
  • Diagnostic Techniques

Background:

  • Peripheral arterial disease (PAD) significantly impacts lower limb circulation.
  • Symptomatic lower limb ischemia presents a challenge in accurate perfusion assessment.
  • Current diagnostic methods may have limitations in evaluating tissue perfusion.

Purpose of the Study:

  • To introduce indocyanine green fluorescence imaging (ICG-FI) as an adjunct to traditional methods.
  • To evaluate ICG-FI's utility in assessing lower limb perfusion in PAD patients.
  • To correlate ICG-FI parameters with established measures of ischemia severity.

Main Methods:

  • 34 PAD patients (Fontaine II-IV) underwent ICG-FI after intravenous ICG injection.
  • Foot perfusion was captured using an infrared camera, generating time-intensity curves.
  • New parameters, T½ and PDE10, were calculated and compared with transcutaneous oxygen pressure (tcPO2).

Main Results:

  • T½ values varied significantly across ischemia severity (FII, FIII, FIV).
  • PDE10 showed moderate correlation with tcPO2 (r²=0.5).
  • A PDE10 cut-off value of 28 accurately predicted critical limb ischemia (100% sensitivity, 86.6% specificity).

Conclusions:

  • ICG-FI provides quantitative evaluation of local tissue perfusion.
  • The method is safe, fast, and non-contact.
  • ICG-FI is potentially valuable for assessing perfusion even at ulcer sites.