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Related Concept Videos

Salivary Glands and Saliva01:23

Salivary Glands and Saliva

The salivary glands, of which there are three pairs known as the parotid, submandibular, and sublingual glands, play a crucial role in maintaining oral health and initiating the digestive process. Positioned near the ears, beneath the masseter muscle, the parotid glands secrete saliva into the oral cavity through the parotid duct of Stensen. Meanwhile, the submandibular glands, located on the floor of the mouth, secrete saliva through channels named submandibular ducts. The sublingual glands,...
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Digestion begins with a cephalic phase that prepares the digestive system to receive food. When our brain processes visual or olfactory information about food, it triggers impulses in the cranial nerves innervating the salivary glands and stomach to prepare for food.
The Physiology of Taste01:24

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The perception of a salty flavor is facilitated by sodium ions within the oral salivary fluid. Upon consumption of a salty substance, salt crystals disassemble, leading to the liberation of its constituents—Na+ and Cl- ions. These ions subsequently dissolve into the salivary fluid present in the oral cavity. The external environment of the gustatory cells experiences an elevation in Na+ concentration, thereby establishing a potent concentration gradient. This gradient propels the diffusion of...
Cranial Nerves: Types Part II01:22

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Cranial nerves are responsible for transmitting motor and sensory information between the brain and various parts of the body. There are twelve pairs of cranial nerves. While the first six innervate the head and neck, the latter six nerves innervate the head and neck, as well as organs and tissues in the thoracic and abdominal cavities. They facilitate communication, expression, and autonomic control within the human body.
Facial Nerve (Cranial Nerve VII)
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The cranial nerves are an important part of the complex network of nerves in the human body. These nerves emerge directly from the brain and are responsible for transmitting essential information between the brain and various parts of the head and neck. There are 12 pairs of cranial nerves, systematically numbered using Roman numerals from I to XII, beginning from the anterior and moving to the posterior of the brain. Each cranial nerve is uniquely identified by names that reflect its function...

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Analysis of Developing Tooth Germ Innervation Using Microfluidic Co-culture Devices
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Analysis of Developing Tooth Germ Innervation Using Microfluidic Co-culture Devices

Published on: August 14, 2015

Interactions between developing nerves and salivary glands.

João N Ferreira1, Matthew P Hoffman

  • 1Matrix and Morphogenesis Section; Laboratory of Cell and Developmental Biology; National Institute of Dental and Craniofacial Research; National Institutes of Health; Bethesda MD USA; Instructor/Lecturer at Faculty of Dentistry; Mahidol University; Rajthevi, Thailand.

Organogenesis
|August 27, 2013
PubMed
Summary
This summary is machine-generated.

Nerves play a crucial role in salivary gland development and regeneration. This review highlights the instructive function of the nervous system on epithelial stem cells during these processes.

Keywords:
cholinergic signalingepithelial progenitorsinnervationneurturinparasympathetic innervationsalivary gland

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Area of Science:

  • Developmental Biology
  • Neurobiology
  • Regenerative Medicine

Background:

  • Adult salivary gland function is primarily to produce and secrete saliva, with neuronal control extensively studied since Pavlov.
  • Salivary gland innervation during development and its influence on organogenesis and regeneration remain less understood.
  • The autonomic nervous system communicates with salivary gland epithelium during organogenesis.

Purpose of the Study:

  • To summarize current knowledge on salivary gland development and regeneration, focusing on the role of nerves.
  • To explore the communication between the autonomic nervous system and salivary gland epithelium during organogenesis.
  • To highlight the emerging theme of the nervous system's instructive role in epithelial stem/progenitor cells.

Main Methods:

  • Literature review integrating neurobiology with epithelial organogenesis.
  • Overview of salivary gland neuroanatomy.
  • Discussion of recent research on nervous system-epithelium interactions.

Main Results:

  • The nervous system plays an instructive role in salivary gland development.
  • Nervous system signaling is crucial for salivary gland regeneration after damage.
  • Emerging evidence suggests the nervous system guides epithelial stem/progenitor cell behavior.

Conclusions:

  • The nervous system is a key regulator of salivary gland organogenesis and regeneration.
  • Understanding neuro-epithelial interactions in salivary glands may offer insights for other organ systems.
  • Further research integrating neurobiology and developmental biology is needed.