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Related Concept Videos

T Cell Types and Functions01:24

T Cell Types and Functions

When T cells with CD4 markers are activated, they give rise to two types of effector cells: helper T cells and regulatory T cells. Meanwhile, T cells with CD8 markers differentiate into effector cytotoxic T cells. The differentiation of CD4 T cells into helper T cell subsets, such as Th1, Th2, and Th17 cells, is dependent on the antigen type, antigen-presenting cell, and regulatory cytokines.
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
Psychosis: Pathophysiology of Schizophrenia and Other Psychotic Disorders01:27

Psychosis: Pathophysiology of Schizophrenia and Other Psychotic Disorders

Schizophrenia is a neurodevelopmental disorder whose origins are rooted in complex genetic components. Despite our burgeoning understanding, the pathophysiology of this disorder remains incompletely deciphered.
Researchers have identified genetic factors that increase susceptibility to schizophrenia, underscoring the intricate interplay between genetics and environment in disease development. At the core of schizophrenia's pathophysiology is excessive dopaminergic neurotransmission within the...
Skin Diseases and Disorders01:23

Skin Diseases and Disorders

Skin is the first line of defense and encounters a variety of microbes. Some pathogenic strains are often the cause of a broad range of infections of the skin and other body systems. These conditions can affect people of all ages and may have different causes, including genetic factors, infections, autoimmune reactions, environmental factors, and lifestyle choices.
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...
Chronic Obstructive Pulmonary Disease-II: Pathophysiology01:20

Chronic Obstructive Pulmonary Disease-II: Pathophysiology

Chronic Obstructive Pulmonary Disease (COPD) pathophysiology is intricate and multifaceted, involving a complex interplay of physiological processes. Understanding these mechanisms is crucial for effectively managing and treating COPD. Here is an in-depth look at the critical elements in the pathophysiology of COPD:
Chronic Inflammation
Asthma: Pathogenesis and Management01:20

Asthma: Pathogenesis and Management

Asthma is a chronic pulmonary condition involving inflammation of the airways, hyper-reactivity, and reversible obstruction of the airways. This condition can significantly impact a person's quality of life, making breathing difficult and leading to distressing symptoms.
Asthma is classified as allergic and non-allergic. Allergens such as dust mites, pollen, and pet dander trigger allergic asthma, while factors like cold air, intense emotions, or exercise can induce non-allergic asthma.
Asthma-II: Pathophysiology and Classification01:26

Asthma-II: Pathophysiology and Classification

Asthma is a prevalent chronic respiratory condition marked by inflammation and hyperresponsiveness of the airways. Its pathophysiology involves complex interactions among inflammatory pathways, immune responses, and neural mechanisms.
Additionally, environmental and genetic factors play crucial roles in determining an individual's susceptibility to asthma and the severity of their condition.
Critical processes in asthma pathophysiology include:

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Related Experiment Video

Updated: May 8, 2026

Lymphocyte Isolation from Human Skin for Phenotypic Analysis and Ex Vivo Cell Culture
10:31

Lymphocyte Isolation from Human Skin for Phenotypic Analysis and Ex Vivo Cell Culture

Published on: April 8, 2016

Pathophysiology of psoriasis.

Rahul Mahajan1, Sanjeev Handa

  • 1Department of Dermatology, Venereology and Leprology, Postgraduate Institute of Medical Education and Research, Chandigarh, India.

Indian Journal of Dermatology, Venereology and Leprology
|August 27, 2013
PubMed
Summary
This summary is machine-generated.

Psoriasis, a chronic inflammatory skin disease, is now understood to involve Th17 cells and skin barrier issues, not just keratinization or Th1 immune problems. This review explores current findings on its complex pathogenesis.

Related Experiment Videos

Last Updated: May 8, 2026

Lymphocyte Isolation from Human Skin for Phenotypic Analysis and Ex Vivo Cell Culture
10:31

Lymphocyte Isolation from Human Skin for Phenotypic Analysis and Ex Vivo Cell Culture

Published on: April 8, 2016

Area of Science:

  • Immunodermatology
  • Pathogenesis of skin diseases

Background:

  • Psoriasis is a chronic inflammatory papulosquamous disease with remissions and relapses.
  • Historically viewed as a keratinization disorder, evolving treatments suggest immune dysregulation.
  • Recent research indicates roles for Th17 cells and skin barrier dysfunction.

Purpose of the Study:

  • To review recent developments in understanding psoriasis pathogenesis.
  • To highlight the roles of Th17 cells and skin barrier dysfunction.
  • To provide an updated perspective on psoriasis etiology.

Main Methods:

  • Literature review of current scientific information.
  • Analysis of recent findings on immune cells and skin barrier function.
  • Synthesis of data to explain psoriasis pathogenesis.

Main Results:

  • Psoriasis involves complex immune dysregulation beyond Th1 cells.
  • T helper 17 (Th17) cells play a significant role in psoriasis.
  • Skin barrier dysfunction is a key feature, similar to atopic dermatitis.

Conclusions:

  • Psoriasis pathogenesis is multifactorial, involving both immune and barrier components.
  • Understanding Th17 cells and skin barrier function is crucial for future psoriasis research.
  • Current information suggests a more complex etiology than previously thought.