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Effective oral psoralen plus ultraviolet a therapy for digital ulcers with revascularization in systemic sclerosis

Tomoko Inoue1, Toshifumi Yamaoka, Hiroyuki Murota

  • 1Department of Dermatology, Osaka University Graduate School of Medicine, Osaka, Japan.

Acta Dermato-Venereologica
|August 27, 2013
PubMed
Abstract

No abstract available in PubMed .

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In the intricate landscape of the gastric lumen, excessive acid secretion disrupts the natural defense mechanisms, weakening the mucus-bicarbonate barrier. This vulnerability allows pepsin to infiltrate epithelial cells, digesting mucosal proteins and triggering erosion, leading to ulcer formation.
In this scenario, mucosal protective agents like sucralfate play an essential role. Sucralfate, a complex of sulfated sucrose and aluminum hydroxide, demonstrates its usefulness in acidic conditions,...

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