Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

General Transcription Factors01:30

General Transcription Factors

6.7K
Tissue-specific transcription factors contribute to diverse cellular functions in mammals. For example, the gene for beta globin, a major component of hemoglobin, is present in all cells of the body. However, it is only expressed in red blood cells because the transcription factors that can bind to the promoter sequences of the beta globin gene are only expressed in these cells. Tissue-specific transcription factors also ensure that mutations in these factors may impair only the function of...
6.7K
Master Transcription Regulators02:23

Master Transcription Regulators

7.7K
Master transcription regulators are regulatory proteins that are predominantly responsible for regulating the expression of multiple genes. Often these genes work in concert to drive a  complex process. Activation of a master transcription regulator can lead to a cascade of transcriptional activation necessary for that outcome. These regulators can directly bind to the regulatory sequences of the various genes involved, or they can indirectly regulate transcription by binding to regulatory...
7.7K
Regulation of Angiogenesis and Blood Supply01:24

Regulation of Angiogenesis and Blood Supply

3.3K
Rapidly dividing tumors, embryos, and wounded tissues require more oxygen than usual, lowering the oxygen concentration in the blood. At low oxygen or hypoxic conditions, an oxygen-sensitive transcription factor called the hypoxia-inducible factor 1 or HIF1 is activated. HIF1 is a dimeric protein of alpha (ɑ) and beta (β) subunits.  Under optimal oxygen conditions, HIF1β is present in the nucleus while HIF1ɑ remains in the cytosol. HIF1ɑ is hydroxylated by prolyl...
3.3K
Transcription Factors02:16

Transcription Factors

82.3K
Tissue-specific transcription factors contribute to diverse cellular functions in mammals. For example, the gene for beta globin, a major component of hemoglobin, is present in all cells of the body. However, it is only expressed in red blood cells because the transcription factors that can bind to the promoter sequences of the beta globin gene are only expressed in these cells. Tissue-specific transcription factors also ensure that mutations in these factors may impair only the function of...
82.3K
Metastasis02:30

Metastasis

6.4K
Metastasis is the spread of cancer cells from the original site to distant locations in the body. Cancer cells can spread via blood vessels (hematogenous) as well as lymph vessels in the body.
Epithelial-to-Mesenchymal Transition
The epithelial-to-mesenchymal transition or EMT is a developmental process commonly observed in wound healing, embryogenesis, and cancer metastasis. EMT is induced by transforming growth factor-beta (TGF-β) or receptor tyrosine kinase (RTK) ligands, which further...
6.4K
RNA Polymerase II Accessory Proteins02:36

RNA Polymerase II Accessory Proteins

10.8K
Proteins that regulate transcription can do so either via direct contact with RNA Polymerase or through indirect interactions facilitated by adaptors, mediators, histone-modifying proteins, and nucleosome remodelers. Direct interactions to activate transcription is seen in bacteria as well as in some eukaryotic genes. In these cases, upstream activation sequences are adjacent to the promoters, and the activator proteins interact directly with the transcriptional machinery. For example, in...
10.8K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Transition metal (Co, Ni, Cu) 1-vinylimidazole templated borates as high-efficiency oxygen reduction catalysts for zinc-air battery.

Dalton transactions (Cambridge, England : 2003)·2026
Same author

Deep-ZOMA: A Deep Learning-Based Approach for Automated Morphometric Analysis of Zebrafish Larvae Ocular Structures.

Translational vision science & technology·2026
Same author

Possible Causal Association Between Thyroid-Related Traits and Diabetic Retinopathy Risk: Evidence From 23 Medication-Taking Traits.

Current eye research·2026
Same author

Drp1-driven fragmentation of scleral mitochondria promotes myopia development.

Proceedings of the National Academy of Sciences of the United States of America·2026
Same author

MIRAGE: a multimodal deep learning framework for interpretable risk assessment of high myopia from genetic and retinal imaging data.

Human molecular genetics·2026
Same author

The MAGIC Cohort Study: Genetic Associations of Anisometropia in Chinese Population.

Genomics, proteomics & bioinformatics·2026

Related Experiment Video

Updated: Jan 17, 2026

A Syngeneic Orthotopic Osteosarcoma Sprague Dawley Rat Model with Amputation to Control Metastasis Rate
07:31

A Syngeneic Orthotopic Osteosarcoma Sprague Dawley Rat Model with Amputation to Control Metastasis Rate

Published on: May 3, 2021

4.2K

EMT transcription factors: implication in osteosarcoma.

Guoqiong Yang1, Jian Yuan, Kanghua Li

  • 1Department of Orthopedics, The Xiangya Hospital of Central South University, 87-Xiangya Road, Changsha, 410008, Hunan, China.

Medical Oncology (Northwood, London, England)
|August 27, 2013
PubMed
Summary

Osteosarcoma, a deadly bone cancer, involves complex pathogenesis linked to epithelial to mesenchymal transition (EMT) transcription factors. Targeting these EMT-TFs shows promise for novel osteosarcoma treatments and metastasis control.

More Related Videos

Three-Dimensional Bone Extracellular Matrix Model for Osteosarcoma
08:07

Three-Dimensional Bone Extracellular Matrix Model for Osteosarcoma

Published on: April 12, 2019

7.6K
Induction and Analysis of Epithelial to Mesenchymal Transition
10:37

Induction and Analysis of Epithelial to Mesenchymal Transition

Published on: August 27, 2013

36.5K

Related Experiment Videos

Last Updated: Jan 17, 2026

A Syngeneic Orthotopic Osteosarcoma Sprague Dawley Rat Model with Amputation to Control Metastasis Rate
07:31

A Syngeneic Orthotopic Osteosarcoma Sprague Dawley Rat Model with Amputation to Control Metastasis Rate

Published on: May 3, 2021

4.2K
Three-Dimensional Bone Extracellular Matrix Model for Osteosarcoma
08:07

Three-Dimensional Bone Extracellular Matrix Model for Osteosarcoma

Published on: April 12, 2019

7.6K
Induction and Analysis of Epithelial to Mesenchymal Transition
10:37

Induction and Analysis of Epithelial to Mesenchymal Transition

Published on: August 27, 2013

36.5K

Area of Science:

  • Oncology
  • Molecular Biology
  • Cancer Research

Background:

  • Osteosarcoma is a primary malignant bone tumor with complex and poorly understood etiology and treatment.
  • Epithelial to mesenchymal transition (EMT) transcription factors (TFs) play a significant role in osteosarcoma development.
  • Overexpression of EMT-TFs like Twist, Snails, and Zebs is implicated in the intricate pathogenesis of osteosarcoma.

Purpose of the Study:

  • To explore the role of EMT-TFs in osteosarcoma pathogenesis.
  • To investigate the potential of targeting EMT-TFs for osteosarcoma treatment.
  • To evaluate the current stage of research on the osteosarcoma-EMT-TFs axis.

Main Methods:

  • Review of recent research studies on osteosarcoma and EMT-TFs.
  • Analysis of the involvement of specific EMT-TFs (Twist, Snail, Zeb) in osteosarcoma.
  • Exploration of therapeutic strategies targeting EMT-TFs.

Main Results:

  • Evidence suggests a significant role for EMT-TFs in osteosarcoma pathogenesis.
  • Targeting EMT-TFs has shown preliminary promise in osteosarcoma treatment research.
  • The research on the osteosarcoma-EMT-TFs axis is still in its early stages.

Conclusions:

  • EMT-TFs are crucial in the complex development of osteosarcoma.
  • Targeting specific EMT-TFs (Twist, Snail, Zeb) offers a potential new therapeutic avenue.
  • Controlling metastasis through EMT-TF inhibition may improve osteosarcoma treatment outcomes.