Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Blood Studies for Cardiovascular System I: Cardiac Biomarkers01:20

Blood Studies for Cardiovascular System I: Cardiac Biomarkers

Cardiac biomarkers are enzymes, proteins, and hormones released into the blood when cardiac cells are injured. They are powerful tools for triaging.
The essential diagnostic tools for detecting myocardial necrosis and monitoring individuals suspected of having acute coronary syndrome (ACS) include:
Troponins
Troponins, particularly cardiac troponins I and T, are the most precise and sensitive markers of myocardial injury. They are detectable within 4-6 hours of myocardial injury and remain...
Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers01:19

Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers

Cardiac biomarkers are critical in diagnosing, prognosing, and managing cardiovascular diseases. Routine measurement of specific biomarkers such as B-type natriuretic peptide (BNP), C-reactive protein (CRP), and homocysteine (Hcy) is common practice in clinical settings to evaluate heart function and predict cardiovascular events.
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...
Acute Inflammation II: Local and Systemic Effects01:25

Acute Inflammation II: Local and Systemic Effects

Acute inflammation produces a coordinated set of local and systemic changes that limit injury, eliminate pathogens, and initiate repair. These responses arise within minutes of infection, trauma, or chemical insult and are driven by vascular alterations and leukocyte-derived mediators. When the stimulus resolves, the reaction typically abates within days.Local EffectsAt the site of injury, arteriolar vasodilation increases blood flow, resulting in redness and warmth. Simultaneously, increased...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Safety of intravascular administration of umbilical-cord-derived mesenchymal stromal cells: an updated systematic review and meta-analysis.

Stem cells translational medicine·2026
Same author

Correction: Plasma apolipoprotein A-I is a causal protective factor in sepsis.

Scientific reports·2026
Same author

Causal effects of serum testosterone on septic shock mortality: a Mendelian randomization study.

Critical care (London, England)·2026
Same author

Plasma apolipoprotein A-I is a causal protective factor in sepsis.

Scientific reports·2025
Same author

Obesity- and Lipid-Related Traits May Causally Contribute to Sepsis-Associated Acute Kidney Injury.

Critical care medicine·2025
Same author

Decreased Clearance of Low-Density Lipoprotein Cholesterol is Causally Associated With Increased Mortality of Septic Shock.

Critical care medicine·2025
Same journal

Chagas Disease: An Opportunistic Infection in AIDS.

Current infectious disease reports·2026
Same journal

Area-based Deprivation Indices and Healthcare-Associated Infections: A Narrative Review of Evidence.

Current infectious disease reports·2025
Same journal

Next Steps: Studying Diabetic Foot Infections with Next-Generation Molecular Assays.

Current infectious disease reports·2024
Same journal

To Tweet or Not to Tweet-a Review of the Viral Power of Twitter for Infectious Diseases.

Current infectious disease reports·2024
Same journal

Web alert.

Current infectious disease reports·2024
Same journal

Bacterial Vaginosis in Postmenopausal Women.

Current infectious disease reports·2023
See all related articles

Related Experiment Video

Updated: May 8, 2026

Evaluation of a Reliable Biomarker in a Cecal Ligation and Puncture-Induced Mouse Model of Sepsis
05:28

Evaluation of a Reliable Biomarker in a Cecal Ligation and Puncture-Induced Mouse Model of Sepsis

Published on: December 9, 2022

Biomarkers in sepsis.

Keith R Walley1

  • 1Centre for Heart Lung Innovation (HLI), St. Paul's Hospital, University of British Columbia, 1081 Burrard Street, Vancouver, BC, Canada, V6Z 1Y6, Keith.Walley@hli.ubc.ca.

Current Infectious Disease Reports
|August 27, 2013
PubMed
Summary
This summary is machine-generated.

Developing effective sepsis biomarkers is crucial for this lethal condition. Rigorous validation is essential to ensure biomarkers improve diagnosis and guide therapy, moving beyond simple outcome prediction.

Related Experiment Videos

Last Updated: May 8, 2026

Evaluation of a Reliable Biomarker in a Cecal Ligation and Puncture-Induced Mouse Model of Sepsis
05:28

Evaluation of a Reliable Biomarker in a Cecal Ligation and Puncture-Induced Mouse Model of Sepsis

Published on: December 9, 2022

Area of Science:

  • Biomarker discovery and development
  • Clinical diagnostics
  • Infectious disease management

Background:

  • Sepsis is a life-threatening condition with diagnostic challenges.
  • Antibiotic use in sepsis can lead to adverse outcomes like antimicrobial resistance.
  • Current diagnostic methods for sepsis are limited, necessitating novel approaches.

Purpose of the Study:

  • To review the development and validation requirements for sepsis biomarkers.
  • To highlight the potential applications of novel sepsis biomarkers beyond prognosis.
  • To discuss the importance of distinguishing infection from non-infectious inflammation.

Main Methods:

  • Review of current literature on sepsis biomarker research.
  • Analysis of validation requirements for clinical utility.
  • Discussion of various classes of candidate biomarkers, including procalcitonin (PCT).

Main Results:

  • Numerous candidate sepsis biomarkers show promise, including proteins, nucleic acids, and metabolomic panels.
  • Procalcitonin (PCT) is the most extensively studied sepsis biomarker.
  • Candidate biomarkers have potential for diagnostic and predictive applications, not just prognostic.

Conclusions:

  • Sepsis biomarker development requires rigorous validation beyond initial association studies.
  • The primary utility of sepsis biomarkers lies in differentiating infection from inflammation and guiding therapy.
  • Future research must focus on prospective, multicenter trials to validate biomarker performance.