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08:17
Generation of a Chronic Obstructive Pulmonary Disease Model in Mice by Repeated Ozone Exposure
Published on: August 25, 2017
New anti-inflammatory targets for chronic obstructive pulmonary disease
1National Heart and Lung Institute, Imperial College School of Medicine, Dovehouse Street, London SW3 6LY, UK. p.j.barnes@imperial.ac.uk
Nature Reviews. Drug Discovery
|August 27, 2013
Summary
New treatments for chronic obstructive pulmonary disease (COPD) are emerging. This review explores promising therapeutic targets to combat airway inflammation and slow disease progression in COPD patients.
Area of Science:
- Pulmonary Medicine
- Inflammation Research
- Pharmacology
Background:
- Chronic obstructive pulmonary disease (COPD) involves chronic airway and lung inflammation, leading to progressive airflow obstruction.
- Current COPD management, primarily long-acting bronchodilators, fails to halt disease progression or suppress inflammation.
- Understanding COPD pathophysiology has revealed novel therapeutic targets for inflammation.
Purpose of the Study:
- To review promising new therapeutic targets for COPD.
- To discuss emerging strategies for managing chronic inflammation in COPD.
- To highlight advancements beyond current bronchodilator treatments.
Main Methods:
- Literature review of recent research on COPD pathophysiology and therapeutic targets.
- Discussion of novel drug classes and biological pathways implicated in COPD.
- Synthesis of information on antioxidants, kinase inhibitors, and cellular senescence targets.
Main Results:
- Several promising therapeutic targets for COPD have been identified.
- New approaches include targeting cellular senescence, microbial colonization, and epigenetic regulation.
- Strategies to overcome corticosteroid resistance are also under investigation.
Conclusions:
- Emerging therapies offer potential to address unmet needs in COPD management.
- Targeting inflammation, cellular processes, and microbial factors may slow COPD progression.
- Future treatments could offer more effective control of chronic inflammation and disease advancement.
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