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A Bioluminescent and Fluorescent Orthotopic Syngeneic Murine Model of Androgen-dependent and Castration-resistant Prostate Cancer
07:25

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Published on: March 6, 2018

Targeted therapy in the treatment of castration-resistant prostate cancer

Christina L Derleth1, Evan Y Yu

  • 1Department of Medicine, Division of Hematology/Oncology, Vanderbilt University, Nashville, Tennessee 37232, USA. christina.l.derleth@vanderbilt.edu

Oncology (Williston Park, N.Y.)
|August 28, 2013
PubMed

Insights

Novel therapeutics extend survival in metastatic castration-resistant prostate cancer but do not improve cure rates due to resistance. Research is exploring alternative targets like the testosterone/androgen receptor pathway to overcome treatment resistance.

Area of Science:

  • Oncology
  • Pharmacology

Background:

  • Metastatic castration-resistant prostate cancer (mCRPC) has seen advancements with novel therapeutics offering survival benefits.
  • However, treatment resistance eventually develops, limiting curative potential.

Purpose of the Study:

  • To review emerging therapeutic strategies targeting resistance mechanisms in mCRPC.
  • To focus on the testosterone/androgen receptor pathway and other alternative biologic targets.

Main Methods:

  • Literature review of recent advancements in mCRPC therapeutics.
  • Analysis of biologic mechanisms underlying treatment resistance.
  • Discussion of novel agents targeting alternative pathways.

Main Results:

  • Novel agents targeting distinct mechanisms extend survival in mCRPC.
  • Resistance to current therapies necessitates exploration of alternative targets.
  • The testosterone/androgen receptor pathway is a key focus for new drug development.

Conclusions:

  • Targeting alternative biologic pathways, including the testosterone/androgen receptor, holds promise for overcoming resistance in mCRPC.
  • Further research into these pathways may lead to improved treatment outcomes and potentially attenuate prostate cancer progression.

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