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Immune Response Against Viral Pathogens01:29

Immune Response Against Viral Pathogens

The immune system's response to viral infections is a complex and coordinated process involving natural killer (NK) cells, T cell-mediated responses, and antibody-mediated responses.
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Antibody Binding Specificity for Kappa (Vκ) Light Chain-containing Human (IgM) Antibodies: Polysialic Acid (PSA) Attached to NCAM as a Case Study
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Neuron-derived IgG protects neurons from complement-dependent cytotoxicity.

Jie Zhang1, Na Niu, Bingjie Li

  • 1Department of Human Anatomy (JZ).

The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society
|August 28, 2013
PubMed
Summary

Neurons produce their own IgG, challenging traditional views of nervous system immunity. This neuron-derived immunoglobulin protects against complement-induced injury and microglial activation, enhancing nervous system stability.

Keywords:
CD64active immunitycomplementendogenous IgGneuron

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Published on: August 21, 2017

Area of Science:

  • Neuroscience
  • Immunology
  • Cell Biology

Background:

  • The nervous system's passive immunity was attributed to the blood-brain barrier.
  • Immunoglobulin G (IgG) was conventionally believed to be produced exclusively by B lymphocytes.

Purpose of the Study:

  • To investigate the production and function of neuron-derived IgG.
  • To determine the role of endogenous IgG in neuronal protection against complement-mediated injury.

Main Methods:

  • Confirmed IgG synthesis in rat cortical neurons via protein and mRNA analysis.
  • Induced neuronal injury using complement and assessed the impact of blocking neuron-derived IgG.
  • Investigated the interaction between neuron-derived IgG, microglia, and complement activation.

Main Results:

  • 69.0 ± 5.8% of cortical neurons were found to be IgG-positive.
  • Blocking neuron-derived IgG increased neuronal death and apoptosis under complement exposure.
  • Neuron-derived IgG attenuated nitric oxide (NO) release from microglia activated by complement.

Conclusions:

  • Neurons synthesize functional IgG, expanding our understanding of nervous system immunity.
  • Neuron-derived IgG provides neuroprotection against complement-induced injury and modulates microglial responses.
  • Endogenous IgG plays a critical role in maintaining nervous system stability.