Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Search research articles

Related Experiment Videos

Chronic persistent hepatitis type B can be a progressive disease when associated with sustained virus replication.

G Fattovich¹, L Brollo, A Alberti

¹Istituto di Medicina Clinica, Università di Padova, Italy.

Journal of Hepatology

|July 1, 1990

Summary

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

A multiomic framework for predicting laryngo-esophageal dysfunction following induction chemotherapy in hypopharyngeal-laryngeal carcinoma.

ESMO open·2025

Same author

A Sputtered Gig-Lox TiO<sub>2</sub> Sponge Integrated with CsPbI<sub>3</sub>:EuI<sub>2</sub> for Semitransparent Perovskite Solar Cells.

The journal of physical chemistry. C, Nanomaterials and interfaces·2025

Same author

A multicenter retrospective analysis of recurrent/metastatic nasopharyngeal cancer from non-endemic areas: Results in the pre-immunotherapy era.

European journal of cancer (Oxford, England : 1990)·2025

Same author

Microbial players in autoimmunity: multicentric analysis of the association between <i>Mycoplasma hominis</i> serostatus and rheumatoid arthritis.

Microbiology spectrum·2025

Same author

Efficacy and safety of the combination of encorafenib/cetuximab with or without binimetinib in patients with BRAF V600E-mutated metastatic colorectal cancer: an AGEO real-world multicenter study.

ESMO open·2024

Same author

Changes in body composition in early breast cancer patients treated with aromatase inhibitors.

Journal of endocrinological investigation·2024

Continuing hepatitis B virus (HBV) replication in carriers with chronic persistent hepatitis predicts disease worsening. Stopping HBV replication correlates with improved liver health and remission.

Area of Science:

Hepatology
Virology
Immunology

Background:

Chronic persistent hepatitis B is a common condition.
Hepatitis B virus (HBV) replication is a key factor in disease progression.
Understanding the link between HBV replication and liver histology is crucial.

Purpose of the Study:

To investigate the association between HBV replication and histologic changes in chronic persistent hepatitis.
To determine if HBV DNA persistence predicts disease progression.
To evaluate the impact of HBV replication cessation on liver disease outcomes.

Main Methods:

Serial liver biopsies were analyzed in 44 chronic persistent hepatitis B patients.
HBV DNA and serologic markers (HBeAg/anti-HBe) were monitored.

Related Experiment Videos

Histologic follow-up over a mean of 4.2 years assessed disease progression or improvement.

Main Results:

32% of HBV DNA positive patients progressed to chronic active hepatitis or cirrhosis.
HBV DNA persistence significantly correlated with liver disease deterioration (p<0.01).
Cessation of HBV replication correlated with biochemical remission and improved histology (p<0.05).

Conclusions:

Continuing HBV replication is a marker for unfavorable evolution in chronic persistent hepatitis.
HBV replication cessation is associated with improved liver histology and remission.
Monitoring HBV replication is vital for predicting disease course in chronic hepatitis B.