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Related Experiment Video

Updated: May 8, 2026

Synthesis of Poly(N-isopropylacrylamide) Janus Microhydrogels for Anisotropic Thermo-responsiveness and Organophilic/Hydrophilic Loading Capability
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Controlled microstructuring of janus particles based on a multifunctional poly(ethylene glycol).

Ekaterina Sokolovskaya1, Jaewon Yoon, Asish C Misra

  • 1Institute of Functional Interfaces (IFG), Karlsruhe Institute of Technology (KIT), Hermann-von-Helmholtz-Platz 1, 76344, Eggenstein-Leopoldshafen, Germany.

Macromolecular Rapid Communications
|August 29, 2013
PubMed
Summary

Researchers created a new sugar-reactive polymer, poly(hydrazide ethylene glycol-co-benzyl glycidyl ether), for targeted drug delivery. This novel material, presented in microparticles, shows potential for glyco-targeted applications.

Keywords:
functional materialsmicroparticlespoly(ethylene glycol)ring-opening polymerizationsugar conjugation

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Microwave-assisted Functionalization of Poly(ethylene glycol) and On-resin Peptides for Use in Chain Polymerizations and Hydrogel Formation

Published on: October 29, 2013

Area of Science:

  • Polymer Chemistry
  • Biomaterials Science
  • Nanotechnology

Background:

  • Development of advanced polymers for drug delivery is crucial.
  • Poly(ethylene glycol) (PEG) based polymers offer biocompatibility and tunable properties.
  • Functionalization of polymers with specific reactive groups enhances targeted delivery capabilities.

Purpose of the Study:

  • To synthesize a novel water-insoluble, multifunctional poly(ethylene glycol) derivative, poly(hydrazide ethylene glycol-co-benzyl glycidyl ether) (P(HZ-co-BnGE)).
  • To demonstrate the utility of P(HZ-co-BnGE) in creating spatially functionalized microparticles for targeted applications.
  • To investigate the selective binding of sugars to the P(HZ-co-BnGE) component of the microparticles.

Main Methods:

  • Synthesis of P(HZ-co-BnGE) via thiol-ene click reaction of poly(allyl glycidyl ether-co-benzyl glycidyl ether) (P(AGE-co-BnGE)).
  • Preparation of bicompartmental microspheres and microcylinders using electrohydrodynamic (EHD) co-jetting.
  • Carbohydrate-lectin-binding assay to confirm selective sugar binding.

Main Results:

  • Successful synthesis of water-insoluble P(HZ-co-BnGE).
  • Fabrication of bicompartmental microstructures with P(HZ-co-BnGE) in a defined compartment.
  • Demonstrated selective binding of 2α-mannobiose to the P(HZ-co-BnGE) compartment.
  • Confirmation of spatially controlled surface reactivity toward sugars.

Conclusions:

  • P(HZ-co-BnGE) is a novel, water-insoluble polymer with potential for creating functional microparticles.
  • EHD co-jetting enables precise spatial control of polymer functionality in microstructures.
  • The selective sugar-binding capability of P(HZ-co-BnGE) highlights its promise for glyco-targeted drug delivery systems.